The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study

Table 2

Adjusted associations between categories of leukocyte and its subtypes and prevalence of benign breast disease^a.

	Quintiles of leukocyte and its subtypes concentration (×10^9/L)					for trend^b, g
	Level 1	Level 2	Level 3	Level 4	Level 5
Serum leukocyte concentration (×10^9/L, range)	3.92–4.71	4.71–5.40	5.40–6.10	6.10–7.40	≥7.40
No. of subjects	1170	1241	1048	1180	1203	—
No. of BBD	258	272	207	242	242	—
Model 1^c	1.00 (reference) d	0.99 (0.82, 1.20)	0.87 (0.71, 1.07)	0.91 (0.75, 1.11)	0.89 (0.73, 1.08)	0.18
Model 2^e	1.00 (reference)	1.01 (0.83, 1.23)	0.90 (0.73, 1.10)	0.95 (0.78, 1.16)	0.93 (0.76, 1.14)	0.40
Model 3^f	1.00 (reference)	1.01 (0.83, 1.22)	0.90 (0.73, 1.11)	0.94 (0.77, 1.16)	0.92 (0.75, 1.14)	0.37
Serum neutrophil concentration (×10^9/L, range)	2.00–2.58	2.58–3.05	3.05–3.60	3.60–4.63	≥4.63
No. of subjects	1193	1161	1101	1215	1172	—
No. of BBD	266	232	218	245	260	—
Model 1^c	1.00 (reference)	0.87 (0.71, 1.06)	0.86 (0.70, 1.05)	0.88 (0.72, 1.07)	0.99 (0.81, 1.21)	0.82
Model 2^e	1.00 (reference)	0.90 (0.74, 1.10)	0.89 (0.72, 1.08)	0.92 (0.75, 1.12)	1.04 (0.85, 1.26)	0.53
Model 3^f	1.00 (reference)	0.89 (0.73, 1.09)	0.88 (0.72, 1.08)	0.91 (0.74, 1.11)	1.01 (0.82, 1.24)	0.71
Serum monocyte concentration (×10^9/L, range)	0.20–0.27	0.27–0.32	0.32–0.38	0.38–0.48	≥0.48
No. of subjects	2390	995	649	912	896	—
No. of BBD	532	203	129	181	176	—
Model 1^c	1.00 (reference)	0.90 (0.75, 1.07)	0.87 (0.70, 1.07)	0.87 (0.71, 1.04)	0.85 (0.70, 1.03)	0.06
Model 2^d	1.00 (reference)	0.87 (0.72, 1.04)	0.85 (0.68, 1.05)	0.85 (0.71, 1.03)	0.86 (0.71, 1.04)	0.06
Model 3^e	1.00 (reference)	0.84 (0.70, 1.01)	0.84 (0.67, 1.04)	0.84 (0.69, 1.02)	0.84 (0.69, 1.02)	0.05
Serum lymphocyte concentration (×10^9/L, range)	1.30–1.60	1.60–1.81	1.81–2.10	2.10–2.60	≥2.60
No. of subjects	1185	1206	1114	1151	1186	—
No. of BBD	275	280	225	229	212	—
Model 1^c	1.00 (reference)	1.00 (0.83, 1.21)	0.84 (0.69, 1.02)	0.82 (0.67, 1.00)	0.72 (0.59, 0.88)	<0.001
Model 2^e	1.00 (reference)	1.01 (0.83, 1.22)	0.85 (0.70, 1.04)	0.83 (0.68, 1.01)	0.75 (0.61, 0.92)	0.001
Model 3^f	1.00 (reference)	0.99 (0.82, 1.2)	0.85 (0.69, 1.04)	0.84 (0.68, 1.02)	0.75 (0.61, 0.92)	0.002
Serum neutrophil-to-lymphocyte ratio (range)	1.05–1.38	1.38–1.66	1.66–2.01	2.01–2.68	≥2.68
No. of subjects	1173	1164	1168	1169	1169	—
No. of BBD	241	228	228	264	260	—
Model 1^c	1.00 (reference)	0.94 (0.77, 1.15)	0.94 (0.77, 1.15)	1.13 (0.93, 1.38)	1.11 (0.91, 1.35)	0.09
Model 2^e	1.00 (reference)	0.95 (0.77, 1.16)	0.96 (0.78, 1.17)	1.15 (0.94, 1.40)	1.12 (0.92, 1.36)	0.08
Model 3^f	1.00 (reference)	0.93 (0.76, 1.14)	0.94 (0.77, 1.15)	1.11 (0.91, 1.36)	1.08 (0.89, 1.32)	0.15

^aBBD, benign breast disease. ^bMultiple logistic regression analysis. ^cModel 1. Crude.^dadjusted odds ratios (95% confidence interval) (all such values). ^eModel 2, Age- and BMI-adjusted. ^fModel 3, adjusted for age, body mass index, smoking status, drinking status, fasting blood glucose, systolic blood pressure, total cholesterol, triglycerides, high-density lipoprotein, low-density lipoprotein, surgery history, menopausal status, and family history of cardiovascular disease. ^gBoldface indicates statistical significance () (or appropriate value).