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| Normal microvessels | DCs with a normal endothelial lining | DCs with a weak expression of CD34 | DCs of contact type | Capillaries in the solid tumor component | Atypical dilated capillaries | The structures with a partial endothelial lining | Lymphatic vessels in lymphoid and polymorphic cell infiltrates |
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Localization | In intra- and peritumoral stroma | In intra- and peritumoral stroma | Mainly in peritumoral stroma | Mainly in intratumoral stroma | In the solid tumor component | In intra- and peritumoral stroma | Mainly in peritumoral stroma | Mainly in peritumoral stroma |
Diameter (μm) | 19.7 ± 10.0 | 101.9 ± 52.2 | 59.4 ± 29.6 | 48.7 ± 10.5 | Collapsed | 109.7 ± 43.9 | — | 85.2 ± 33.3 |
Shape | Regular | Regular and irregular | Regular | Regular | Linear | Irregular | Irregular | Regular |
Contours | Smooth | Smooth | Smooth | Smooth | Smooth | Uneven | Uneven | Smooth |
Arrangement of the endothelial cells | Normal | Normal | Normal | Normal | Normal | Chaotic | Chaotic | Normal |
The severity of CD34 expression | Intensively | Intensively | Weakly | Moderately | Intensively | Intensively | Intensively | Moderately |
Podoplanin staining | Some positive | Some positive | Negative | Negative | Negative | Some positive | Some positive | All positive |
Content | Erythrocytes, white blood cells | Erythrocytes, white blood cells | Often absent | Absent or white blood cells | — | Absent, erythrocytes, white blood cells | Absent or tumor mass | Lymphocytes and other white blood cells |
Tumor emboli in the lumen | Rarely | Rarely | Rarely | Rarely | Rarely | Often | Often | Rarely |
CD34-positive cells in the lumen | Rarely | Rarely | Absent | Absent | Absent | Often | Often | Absent |
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