Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment

Table 1

Genetic alterations in gioblastoma.

Gene	Alteration	Signaling pathway	References
IDH	Mutation	Metabolism	[11]
EGFR	Deletion (EGFRvIII); Mutation; Translocation; Amplification	RTK signaling
ATRX	Mutation	Genome integrity	[12]
TP53	Wild-type (no mutations)	Cell cycle pathways	[13]
PTEN	Deletion; Mutation	MAPK and PI3K/mTOR signaling pathways	[13]
RB1; CDKN2A	Loss	Rb pathway	[14]
PTPRZ1	Fusion	RTK signaling	[15]
KIT	Amplification; Mutation	Growth factor	[6]
PDGFRA	Amplification	Growth factor	[16]
MDM2	Amplification	Cell cycle pathways	[17]
NF1	Deletion; Mutation	MAPK and PI3K/mTOR signaling pathways	[16]
FGFR1, FGFR3	Translocation (FGFR3-TACC3)	Growth factor	[6, 18]
MET	Amplification; Translocation	Growth factor	[6]
TERT	Promoter mutation	Telomere maintenance	[17]