An Early Myeloma Bone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the Extracellular Matrix

Figure 2

TRAP staining of femora injected with PBS (a, b) and MOPC315.BM.Luc cells (c, d) at day 21. (a–d) TRAP staining of the femoral condyle region to visualize osteoclast activity (purple) at day 21. (b, d) Detailed view of the rectangular area in (a) and (c) showing osteoclast activity on the surface of trabecular bone (purple, black arrows). Blue indicates nuclei (haematoxylin) counterstain.