Effectiveness of a Global Multidisciplinary Supportive and Educational Intervention in Thermal Resort on Anthropometric and Biological Parameters, and the Disease-Free Survival after Breast Cancer Treatment Completion (PACThe)

Table 4

Variation in diet and body parameters between one-year follow-up and allocation.

		SPA arm (n = 55)			CTR arm (n = 49)			value effect of
		≤25 (n = 29)	]25–30] (n = 15)	>30 (n = 11)	≤25 (n = 23)	25–30 (n = 19)	>30 (n = 7)	SPA	Time	BMI
Diet parameters
Total energy intake	kcal/d	−41.7 ± 400.5	+25.5 ± 556.4	−400.1 ± 527.6	−227.9 ± 362.6	+165.6 ± 410.4	−437.6 ± 955.1	0.91	0.039	0.15
		(-0.02%)	(+10.8%)	(−18.7%)	(-12.3%)	(+20.1%)	(−10.3%)
Protein intake	g/d	−4.6 ± 17.9	+3.2 ± 25.5	−5.8 ± 19.0	−1.78 ± 27.1	+5.1 ± 21.4	−15.4 ± 45.4	0.71	0.24	0.35
		(-3.9%)	(+17.5%)	(-3.1%)	(+6.0%)	(+26.1%)	(−1.4%)
Carbohydrate intake	g/d	+8.4 ± 52.2	+6.1 ± 63.7	−57.9 ± 78.3	−28.4 ± 54.8	+6.7 ± 51.2	−46.7 ± 121.1	0.84	0.10	0.38
		(+10.1%)	(+16.7%)	(−21.5%)	(−9.8%)	(+7.5%)	(−1.5%)
Lipid intake	g/d	−5.5 ± 26.4	−1.3 ± 36.4	−12.7 ± 25.2	−9.4 ± 19.8	+13.0 ± 13.0	−24.6 ± 45.4	0.89	0.099	0.15
		(+0.2%)	(+24.0%)	(−13.8%)	(−7.9%)	(+67.3%)	(−21.1%)
Body parameters
Body weight	kg	−0.10 ± 2.16	+1.47 ± 4.00	−0.73 ± 5.76	−0.24 ± 2.67	+0.26 ± 3.86	+0.93 ± 2.41	0.56	0.45	<10^–7
		(−0.2%)	(+2.2%)	(−0.3%)	(−0.5%)	(+0.4%)	(+1.1%)
Lean mass (LM)	%	+1.03 ± 3.63	−0.25 ± 1.66	−0.34 ± 5.85	0.00 ± 3.20	−0.02 ± 3.14	+3.09 ± 7.07	0.18	0.85	<10^–7
		(+1.7%)	(−0.4%)	(−0.0%)	(−0.0%)	(+0.1%)	(+6.0%)
Fat mass (FM)	%	−0.85 ± 3.50	+0.25 ± 1.66	+0.31 ± 5.90	−0.00 ± 3.20	+0.02 ± 3.14	−1.64 ± 6.05	0.11	0.86	<10^–7
		(−2.7%)	(+0.6%)	(+2.0%)	(0.0%)	(+0.6%)	(-3.6%)
LM/FM ratio		+0.10 ± 0.39	−0.01 ± 0.14	−0.03 ± 0.37	+0.04 ± 0.40	−0.01 ± 0.29	+0.17 ± 0.39	0.20	0.77	<10^–7
		(+5.0%)	(−0.6%)	(+1.6%)	(+1.7%)	(+0.9%)	(+14.4%)
Cell mass	kg	+1.34 ± 6.57	+0.95 2.21	+0.54 ± 3.02	−0.83 ± 4.52	−0.66 ± 4.74	+2.15 ± 5.82	0.19	0.34	<10^–7
		(+6.8%)	(+5.2%)	(+2.0%)	(−2.8%)	(−1.7%)	(+7.3%)
Total water	l	+0.25 ± 1.62	+0.51 ± 1.45	+0.13 ± 2.53	−0.06 ± 1.02	+0.11 ± 1.86	+1.07 ± 5.15	0.22	0.40	<10^–7
		(+0.9%)	(+1.7%)	(+0.8%)	(−0.1%)	(+0.5%)	(+3.2%)
Extracellular water	%	+0.51 ± 1.72	−0.67 ± 1.67	+0.02 ± 2.33	+1.14 ± 4.1	0.98 ± 3.72	−3.97 ± 10.72	0.80	0.86	<10^–7
		(+2.0%)	(−2.3%)	(+0.6%)	(+4.9%)	(+4.3%)	(−7.2%)
Intracellular water	%	+2.21 ± 9.32	+0.61 ± 1.32	−0.08 ± 1.99	−0.35 ± 4.76	−0.59 ± 4.68	+1.65 ± 4.55	0.28	0.53	0.00012
		(+7.7%)	(+3.2%)	(−0.2%)	(−1.3%)	(−1.9%)	(+7.0%)
Tricipital fold thickness	cm	+0.46 ± 3.74	−0.57 ± 7.78	−3.25 ± 5.41	+0.23 ± 5.05	+2.98 ± 5.60	−2.51 ± 4.95	0.36	0.69	<10^–7
		(+10.7%)	(+1.5%)	(−7.5%)	(+14.1%)	(+25.3%)	(−6.3%)
Arm circumference	cm	−0.10 ± 1.77	−1.00 ± 1.49	−1.46 ± 1.94	−0.46 ± 1.71	−0.32 ± 2.16	−0.93 ± 2.01	0.58	0.32	<10^–7
		(−0.3%)	(−3.1%)	(−3.6%)	(−1.7%)	(−1.1%)	(−2.4%)
Waist circumference (WC)	cm	−2.93 ± 4.41	+0.43 ± 3.68	−1.09 ± 5.00	−0.46 ± 5.65	+1.45 ± 8.51	−3.36 ± 6.24	0.73	0.81	<10^–7
		(−3.7%)	(−0.4%)	(−1.0%)	(−0.4%)	(+2.7%)	(−3.0%)
Hip circumference (HC)	cm	−0.59 ± 2.80	1.77 ± 2.83	0.23 ± 5.85	−1.30 ± 3.56	−0.13 ± 3.71	2.79 ± 5.53	0.80	0.66	<10^–7
		(−0.6%)	(+1.7%)	(+0.4%)	(−1.1%)	(−0.1%)	(2.5%)
WC/HC ratio		−0.03 ± 00.05	−0.01 ± 0.02	−0.01 ± 0.07	+0.01 ± 0.05	+0.2 ± 0.08	−0.05 ± 0.06	0.66	0.61	<10^–7
		(−2.9%)	(−1.5%)	(−1.1%)	(+0.9%)	(+3.1%)	(−4.9%)

Variation for each parameter is expressed in raw value (one-year follow-up value minus allocation value) and in percentage of the allocation value: + sign indicates an increase and –sign indicates a decrease. Two-way ANOVA was used to compare longitudinal variations between allocation arms (SPA effect), or one-year follow-up (time effect), or BMI groups (BMI effect), but without interaction test because of unequal class sizes. All tests were two-sided, and the nominal level of significance was 5%. Significant p values are indicated in bold.