Effectiveness of a Global Multidisciplinary Supportive and Educational Intervention in Thermal Resort on Anthropometric and Biological Parameters, and the Disease-Free Survival after Breast Cancer Treatment Completion (PACThe)
Table 5
Variation in biological parameters between one-year follow-up and allocation.
SPA arm (n = 55)
CTR arm (n = 49)
value effect of
≤25
25–30
>30
≤25
25–30
>30
SPA
Time
BMI
(n = 29)
(n = 15)
(n = 11)
(n = 23)
(n = 19)
(n = 7)
Glucose
mmol/l
0.007 ± 0.446
0.459 ± 0.748
0.749 ± 1.358
−0.089 ± 0.326
0.226 ± 0.394
1.75 ± 2.775
0.23
0.04
<10–6
(0.6%)
(8.9%)
(15.9%)
(−1.6%)
(4.4%)
(25.9%)
HDL-cholesterol
mmol/l
−0.438 ± 1.471
−0.241 ± 1.34
−0.542 ± 1.31
−0.436 ± 1.384
−0.333 ± 1.635
−0.028 ± 0.198
0.41
0.027
0.007
(−5.6%)
(3.4%)
(−13%)
(−4.8%)
(7%)
(−1.3%)
Transthyretin
g/l
0.001 ± 0.038
0.009 ± 0.026
−0.005 ± 0.027
0.001 ± 0.033
−0.007 ± 0.031
0.002 ± 0.051
0.041
0.75
0.79
(1%)
(3.5%)
(−1.5%)
(0.8%)
(−2%)
(3.2%)
C-reactive protein
mg/l
−0.146 ± 1.142
0.238 ± 2.818
−0.127 ± 1.481
0.264 ± 1.168
−0.135 ± 4.736
−1 ± 5.545
0.11
0.73
<10–7
(11.1%)
(27.3%)
(8.9%)
(41.8%)
(41.1%)
(−6.6%)
Insulin
mUI/l
0.17 ± 3.79
1.97 ± 4.59
2.51 ± 10.19
0.22 ± 6.58
4.47 ± 10.51
4.53 ± 6.24
0.41
0.035
<10–7
(25.7%)
(115.7%)
(58.4%)
(36.1%)
(50.9%)
(78.4%)
IGF-1
μg/l
−0.79 ± 27.51
−26.61 ± 27.25
−18.78 ± 23.9
−13.18 ± 39.9
−12.41 ± 34.83
9.13 ± 16.55
0.32
0.072
0.31
(6.3%)
(−19.7%)
(−24%)
(−4.2%)
(−12.2%)
(16.5%)
Leptin
μg/l
−0.03 ± 1.57
−0.02 ± 2.72
−2.42 ± 6.24
0.12 ± 2.38
1.64 ± 6.28
−0.93 ± 3.78
0.66
0.81
<10–7
(15.6%)
(9%)
(−2.4%)
(21.7%)
(23.6%)
(−7.4%)
Adiponectin
mg/l
2.33 ± 4.19
1.29 ± 2.3
0.57 ± 1.3
0.99 ± 2.51
1.15 ± 2.65
0.65 ± 1.01
0.33
0.082
0.022
(32.6%)
(17.3%)
(18%)
(13.9%)
(11.5%)
(5.6%)
Leptin/adiponectin ratio
−0.1 ± 0.27
−0.08 ± 0.52
−1.68 ± 2.92
0.13 ± 1.21
1.2 ± 4.07
−0.27 ± 0.29
0.73
0.91
2 × 10–6
(−2.9%)
(−0.4%)
(−18%)
(24.2%)
(16.6%)
(−13.6%)
Testosterone
nmol/l
−0.033 ± 0.299
−0.013 ± 0.098
0.045 ± 0.347
−0.051 ± 0.244
0.015 ± 0.332
0.029 ± 0.757
0.086
0.83
0.27
(−3.6%)
(5%)
(10.7%)
(−5%)
(3.4%)
(21.8%)
CA 15-3
kU/l
2.32 ± 3.08
0.62 ± 1.78
0.27 ± 1.71
−5.32 ± 28.45
1.56 ± 2.06
2.71 ± 1.48
0.04
0.68
0.07
(18.2%)
(6.8%)
(4.7%)
(1.4%)
(12.5%)
(14%)
Variation for each parameter is expressed in raw value (one-year follow-up value minus allocation value) and in percentage of the allocation value: + sign indicates an increase and – sign indicates a decrease. Two-way ANOVA was used to compare longitudinal variations between allocation arms (SPA effect), or one-year follow-up (time effect), or BMI groups (BMI effect), but without interaction test because of unequal class sizes. All tests were two-sided, and the nominal level of significance was 5%. Significant p values are indicated in bold.
