Attenuated Total Reflection-Fourier Transform Infrared (ATR-FTIR) Spectroscopy Analysis of Saliva for Breast Cancer Diagnosis

Figure 3

Comparison of the second-derivative absorbance of the statistically significant peak 1041 cm⁻¹ between the three study groups. (a) Average second-derivative spectra between 1060–1020 cm⁻¹ highlighting the wavenumber 1041 cm⁻¹ for breast cancer (red line), benign breast disease (black line), and control saliva (blue line). (b) Scatter plot of the statistically significant wavenumber 1041 cm⁻¹ for breast cancer (red), benign breast disease (black), and control saliva (blue). The line represents the mean, and the error bars (whiskers) represent the standard error of the mean (SEM) (, comparison of groups via the unpaired t-test with Welch’s correction). ROC curves made from the wavenumber 1041 cm⁻¹ for (c) breast cancer vs. control and (d) breast cancer vs. benign breast disease. Results about area under the curve (AUC), value, cutoff, sensitivity, and specificity are being shown near the ROC curve. Statistically significant differences are represented by ().

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