Detection of Fusion Genes Using a Targeted RNA Sequencing Panel in Gastrointestinal and Rare Cancers

Table 2

Individual patients’ information and concomitant genomic alterations.

No	Sex	Age	Cancer type	Histology	Strong fusion	SNV/indel
1	M	48	CRC	M/D ADC	TPM3 ⟶ NTRK1	KRAS G12V
2	F	74	CRC	M/D ADC	TPM3 ⟶ NTRK1,
3	F	78	STS	Angiosarcoma	PEAR1 ⟶ NTRK1
4	M	68	BTC	M/D ADC	FGFR3 ⟶ TACC3,
5	M	58	GC	M/D ADC	FGFR3 ⟶ TACC3,
6	F	53	CRC	M/D ADC	NCOA4 ⟶ RET
7	F	32	GC	P/D ADC	INTERGENIC ⟶ CSMD1 ⟶ RAF1
8	F	35	Melanoma	Skin melanoma	MAPRE2 ⟶ RAF1
9	M	58	STS	Retroperitoneal leiomyosarcoma	IGH-AS ⟶ RAF1,; AXL ⟶ LOC440300
10	F	60	Pancreas cancer	M/D ADC	IQSEC1 ⟶ RAF1	KRAS G12D
11	M	56	CRC	SRCC	MAP7D1 ⟶ EGFR	KRAS G13D; PIK3CA H1047R
12	M	57	CRC	W/D ADC	LACE1 ⟶ ROS1	KRAS G12A
13	M	80	BTC	P/D ADC	SP6 ⟶ ALK,; THADA ⟶ VPS36
14	M	65	CRC	W/D ADC	AXL ⟶ ALK
15	M	66	GC	P/D ADC	AXL ⟶ IGH-AS
16	M	56	BTC	M/D ADC	FGFR2 ⟶ NRAP
17	M	56	GC	SRCC	CLDN18 ⟶ ARHGAP26
18	M	47	GC	P/D ADC	CLDN18 ⟶ ARHGAP26
19	M	67	BTC	ADC	BRAF ⟶ INTERGENIC ⟶ PTMA
20	M	51	STS	Extraskeletal myxoid chondrosarcoma	EWSR1 ⟶ NR4A3,; BRAF ⟶ UNALIGNED ⟶ LOC100996643
21	M	50	STS	Liver leiomyosarcoma	CTBP2 ⟶ NOTCH2
22	F	49	STS	Uterine leiomyosarcoma	ENO2 ⟶ ETV4
23	M	56	STS	Retroperitoneal; Malignant SFT	GNA13 ⟶ PRKCA
24	F	61	BTC	P/D ADC	LOC100506217 ⟶ RELA
25	M	52	CRC	M/D ADC	ESR1 ⟶ KIAA1731

CRC: colorectal cancer; GC: gastric cancer; BTC: biliary tract cancer; STS: soft tissue sarcoma; W/D ADC: well-differentiated adenocarcinoma; M/D ADC: moderately differentiated adenocarcinoma; P/D ADC: poorly differentiated adenocarcinoma; SRCC: signet ring cell carcinoma.