Role of HSP60/HSP10 in Lung Cancer: Simple Biomarkers or Leading Actors?

Figure 1

The tumor-suppressor FHIT protein interacts with HSP60, and possibly is folded by the chaperoning complex HSP60/HSP10 inside mitochondria. Therefore, any quantitative or qualitative defect of HSP60 (chaperonopathy by defect) may decrease the level of functional FHIT protein, causing a failure of tumor suppression and favoring carcinogenesis.