Journal of Oncology

Research Article

ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility

Table 2

Genetic variants in the alcohol metabolism genes and their association with CRC risk.


Chr	SNP	Position	Gene	Location	Effect allele	MAF cases	MAF controls	P^a	OR (95% CI)^b	P^b	FDR	P^c

4	rs55735703	100057727	ADH4	Missense	A	0.01	0.01	1.0000	0.70 (0.31–1.58)	0.3945	0.7976	0.3830
4	rs698	100260789	ADH1C	Missense	G	0.08	0.09	0.5748	0.92 (0.67–1.27)	0.6049	0.8483	0.0664
4	rs1693482	100263965	ADH1C	Missense	A	0.08	0.09	0.7793	0.92 (0.66–1.27)	0.6117	0.8483	0.0645
4	rs971074	100341861	ADH7	Synonymous	A	0.11	0.13	1.0000	0.82 (0.63–1.07)	0.1429	0.6576	0.7415
9	rs2228093	38396002	ALDH1B1	Missense	A	0.37	0.39	0.7109	0.90 (0.75–1.09)	0.2769	0.7976	0.0895
9	rs2073478	38396065	ALDH1B1	Missense	A	0.31	0.32	1.0000	0.97 (0.80–1.17)	0.7128	0.8773	0.0368
9	rs113083991	38396271	ALDH1B1	Missense	A	0.02	0.03	0.3328	0.82 (0.47–1.44)	0.4875	0.8483	0.6004
9	rs8187929	75540504	ALDH1A1	Missense	A	0.03	0.04	0.5069	0.78 (0.48–1.27)	0.3153	0.7976	0.5290
11	rs58465018	67430748	ALDH3B2	Missense	G	0.03	0.03	0.3521	1.05 (0.63–1.76)	0.8450	0.9013	0.7338
11	rs1551886	67430762	ALDH3B2	Missense	A	0.09	0.09	0.2544	1.00 (0.74–1.37)	0.9753	0.9753	0.6181
11	rs3741178	67434048	ALDH3B2	Missense	T	0.04	0.02	0.2544	2.13 (1.24–3.68)	0.0064	0.1024	0.7677
11	rs308341	67795299	ALDH3B1	Missense	A	0.26	0.27	0.1553	0.95 (0.78–1.17)	0.6362	0.8483	0.4126
11	rs3751082	67795353	ALDH3B1	Missense	A	0.26	0.27	0.0261	0.92 (0.75–1.12)	0.3988	0.7976	0.4694
12	rs671	112241766	ALDH2	Missense	A	0.28	0.25	0.0199	1.15 (0.94–1.41)	0.1642	0.6576	0.1748
15	rs4646626	58256127	ALDH1A2	Missense	A	0.31	0.31	1.0000	0.98 (0.81–1.18)	0.8123	0.9013	0.3010
15	rs3803430	101445815	ALDH1A3	Missense	G	0.05	0.06	0.2871	0.76 (0.52–1.12)	0.1644	0.6576	0.0916

Note: SNP, single nucleotide polymorphism; MAF, minor allele frequency. ^aTest for the Hardy–Weinberg equilibrium in the control samples. ^bCalculated by the logistic regression model adjusted for sex, age, smoking status, and drinking status. ^cCalculated by the logistic regression model.