Review Article
Physical Properties of Nanoparticles That Result in Improved Cancer Targeting
Table 6
Effect of NPs surface charge on tumor uptake: it seems that positively charged NPs and slightly negative display a good tumor uptake.
| Authors | Nanoparticle types and charge | Treatment/study | Efficacy |
| Xiao et al. [44] | NPs with high negative and high positive charge | Tumor cellular uptake | High uptake of slight negative and slight positive NPs | Gou et al. [111] | NPs with different charge | Tumor cell uptake | Delayed charge reversal strategy could improve therapeutic effect | Graf et al. [112] | High positive NPs | Stability in physiological media | Effective cellular internalization | He et al. [45] | Polymeric NPs negative(−40 mV) and positive charge (+35 mV) | Tumor uptake | Slight negative charge accumulate more efficiently in tumor | Chen et al. [113] | Positive and negative NPs | Tumor uptake | High uptake of positively charged Nps increase uptake of both charge under hypoxic conditions | Stylianopoulos et al. [105] | Positive NPs switched into neutral inside the tumor | Cancer (tumor targeting) | Positive NPs: Effective tumor targeting & neutral charge allowed quicker diffusion of the nanoparticles to the tumor tissue |
|
|