Journal of Oncology / 2020 / Article / Tab 7 / Review Article
Physical Properties of Nanoparticles That Result in Improved Cancer Targeting Table 7 Effect of adding different types of coatings to the NPs.
Author NPs type and size Type of added ligant Treatment Effect/distribution Benefit Liu et al. [52 ] Coated BVP-PLA-NPs 177 and 319 nm BVP IV administration Liver, spleen, heart, brain NPs penetrate the BBB, avoid the RES, prolong the half-life of BVP Takeuchi et al. [51 ] Gold NPs 20, 40 and 80 nm PEG IV administration Usefulness of PEG with smaller NPs size Reduced accumulation in liver, spleen, improved delivery to the brain Ezealisiji and Okorie [72 ] Ag NPs Peg, PG, Tween, NaLSo4 Dermatological application (skin penetration) Maximum penetration efficacy of NaLSo4 followed by PG Improved skin penetration Hu et al. [125 ] PEG-PLA nanoparticles Peptide F3 PEG-PLA nanoparticles IV treatment of glioma Enhanced accumulation at the tumor site and deep penetration into the glioma parenchyma Improved parenchyma penetration
The maximum penetration was achieved by the NaLSO4 followed by PG and then PEG [
105 ]. Coated BVP-PLA NPs also avoided the RES and prolonged the half-life of NPs [
111 ].