Physical Properties of Nanoparticles That Result in Improved Cancer Targeting

Table 7

Effect of adding different types of coatings to the NPs.

Author	NPs type and size	Type of added ligant	Treatment	Effect/distribution	Benefit
Liu et al. [52]	Coated BVP-PLA-NPs 177 and 319 nm	BVP	IV administration	Liver, spleen, heart, brain	NPs penetrate the BBB, avoid the RES, prolong the half-life of BVP
Takeuchi et al. [51]	Gold NPs 20, 40 and 80 nm	PEG	IV administration	Usefulness of PEG with smaller NPs size	Reduced accumulation in liver, spleen, improved delivery to the brain
Ezealisiji and Okorie [72]	Ag NPs	Peg, PG, Tween, NaLSo4	Dermatological application (skin penetration)	Maximum penetration efficacy of NaLSo4 followed by PG	Improved skin penetration
Hu et al. [125]	PEG-PLA nanoparticles	Peptide F3 PEG-PLA nanoparticles	IV treatment of glioma	Enhanced accumulation at the tumor site and deep penetration into the glioma parenchyma	Improved parenchyma penetration

The maximum penetration was achieved by the NaLSO4 followed by PG and then PEG [105]. Coated BVP-PLA NPs also avoided the RES and prolonged the half-life of NPs [111].