Somatic Mutation Profiling of Intrahepatic Cholangiocarcinoma: Comparison between Primary and Metastasis Tumor Tissues

Table 2

Genes with differentially mutation frequency in PSs and MSs.

Gene	Alteration frequency in primary ICC (%)	Alteration frequency in metastatic ICC (%)	value	Pathway
LRP1B	10.5	22.4	0.03	None
BRAF	11.1	0	0.01	RTK.RAS
EPCAM	0	4.0	0.01	None
GNA13	0	4.0	0.01	None
MYCL	0	4.0	0.01	None
PARP2	0	4.0	0.01	DDR
YES1	0	4.0	0.01	None
STK24	0.7	6.1	0.01	None
TSC1	2.0	8.1	0.04	PI3K