Gene Expression, Network Analysis, and Drug Discovery of Neurofibromatosis Type 2-Associated Vestibular Schwannomas Based on Bioinformatics Analysis

Table 1

GO analysis of differentially expressed genes.

Category	Term	Count	value	FDR
BP	GO:0007155 ∼ cell adhesion	38	<0.001	<0.001
BP	GO:0006954 ∼ inflammatory response	34	<0.001	<0.001
BP	GO:0006955 ∼ immune response	32	<0.001	<0.001
BP	GO:0007165 ∼ signal transduction	58	<0.001	0.0054
BP	GO:0051897 ∼ positive regulation of protein kinase B signaling	12	<0.001	0.0203
BP	GO:0070374 ∼ positive regulation of ERK1 and ERK2 cascade	17	<0.001	0.0261
BP	GO:0043547 ∼ positive regulation of GTPase activity	34	<0.001	0.0265
BP	GO:0030198 ∼ extracellular matrix organization	18	<0.001	0.0285
BP	GO:0030335 ∼ positive regulation of cell migration	17	<0.001	0.0488
CC	GO:0005615 ∼ extracellular space	87	<0.001	<0.001
CC	GO:0005887 ∼ integral component of plasma membrane	88	<0.001	<0.001
CC	GO:0005886 ∼ plasma membrane	177	<0.001	<0.001
CC	GO:0005578 ∼ proteinaceous extracellular matrix	31	<0.001	<0.001
CC	GO:0009986 ∼ cell surface	42	<0.001	<0.001
CC	GO:0070062 ∼ extracellular exosome	121	<0.001	<0.001
CC	GO:0005576 ∼ extracellular region	81	<0.001	<0.001
CC	GO:0031012 ∼ extracellular matrix	28	<0.001	<0.001
CC	GO:0009897 ∼ external side of plasma membrane	21	<0.001	<0.001
CC	GO:0045121 ∼ membrane raft	20	<0.001	0.0020
CC	GO:0016021 ∼ integral component of membrane	179	<0.001	0.0020
CC	GO:0005925 ∼ focal adhesion	27	<0.001	0.0122
CC	GO:0045202 ∼ synapse	17	<0.001	0.0224
MF	GO:0008201 ∼ heparin binding	20	<0.001	<0.001
MF	GO:0005178 ∼ integrin binding	14	<0.001	0.0041