Risk Stratification in Advanced Biliary Tract Cancer: Validation of the A.L.A.N. Score

Table 2

Comparison of median OS among the A.L.A.N. subgroups.

A.L.A.N. subgroups	Low risk (0 points)	Intermediate risk (1–2 points)	High risk (3-4 points)	value
This study: median OS (95% CI), m	21.9 (10.3–30.9)	11.4 (6.4–18.0)	4.3 (3.0–8.6)	0.017
Original A.L.A.N. exploratory cohort: median OS (95% CI), m	22 (14–32)	12 (8–15)	5 (2–8)	<0.001
Original A.L.A.N. validation cohort: median OS (95% CI), m	12.9 (8.7–26.4)	9.3 (7.4–14.7)	4.3 (2.6–9.2)	0.005

OS: overall survival; CI: confidence interval; m: months. Significant values are depicted in bold.