Mucinous Histology, BRCA1/2 Mutations, and Elevated Tumor Mutational Burden in Colorectal Cancer

Table 2

Association of different variables and mutation count involved in discrimination between the BRCA-mutated/high-mutation-count group and the BRCA-mutated/low-mutation-count group. Significant values are marked in bold.

Parameters	Test for mutation	value for mutation count	Corrected value for mutation count	Test for BRCA_mut_group	value for BRCA_mut_group	Corrected value for BRCA_mut_group
Age at diagnosis	Spearman	value >0.05	value >0.1	Mann–Whitney	value >0.05	value >0.1
Sex	Mann–Whitney	value >0.05	value >0.1	Chi-square	value >0.05	value >0.1
First site of metastasis	Kruskal–Wallis	value >0.05	value >0.1	Fisher’s exact test	value >0.05	value >0.1
Fraction of genome altered	Spearman	value <0.05	value <0.05	Wilcoxon	value <0.05	value <0.05
Tumor sample histology	Mann–Whitney	value <0.05	value <0.05	Chi-square	value <0.05	value <0.1
Stage at diagnosis	Kruskal–Wallis	value <0.05	value <0.05	Fisher’s exact test	value <0.05	value <0.05
Primary tumor location	Mann–Whitney	value <0.05	value >0.1	Chi-square	value <0.05	value >0.1
MSI score	Spearman	value <0.05	value <0.05	Mann–Whitney	value <0.05	value <0.05

Threshold for significance after correction for multiple hypotheses was 0.1.