Clinical Significance of the Interaction between Human Papillomavirus (HPV) Type 16 and Other High-Risk Human Papillomaviruses in Women with Cervical Intraepithelial Neoplasia (CIN) and Invasive Cervical Cancer
Table 1
Sociodemographic and virological data according to the severity of cervical intraepithelial neoplasia (CIN) at the enrollment.
CIN 1 (n = 1811)
CIN 2 (n = 405)
CIN 3 (n = 678)
Invasive cancer (n = 91)
N. 1811 (%)
N. 405 (%)
N. 678 (%)
N. 91 (%)
Age (mean ± SD)
36.8 ± 10.4
35.06 ± 9.3
37.33 ± 9.1
43.76 ± 9.1
Parity
784 (43.3)
176 (43.46)
298 (43.9)
40 (44)
HIV positive
72 (4)
26 (6.42)
47 (6.9)
4 (4.4)
Nonsmokers
1410 (77.8)
322 (79.5)
528 (77.9)
64 (70.3)
<10 cig/day
197 (10.9)
47 (11.6)
85 (12.5)
16 (17.6)
≥10 cig/day
204 (11.3)
36 (8.9)
65 (9.6)
11 (12.1)
Contraceptive use
No
933 (51.5)
212 (52.3)
382 (56.3)
42 (46.1)
Barrier
155 (8.6)
32 (8)
41 (6)
10 (11)
Hormonal
702 (38.8)
158 (39)
249 (36.7)
37 (40.7)
IUD
21 (1.2)
3 (0.7)
6 (0.9)
2 (2.2)
Pap smear results
ASCUS
584 (33.2)
125 (30.9)
148 (21.8)
5 (5.5)
LSIL
1087 (60.0)
120 (29.6)
212 (31.3)
10 (11)
HSIL-ASCH
127 (7.0)
141 (34.8)
253 (37.3)
28 (30.8)
AGUS
9 (0.5)
12 (3)
25 (3.7)
11 (12.1)
Cancer
4 (0.2)
7 (1.7)
40 (5.9)
37 (40.7)
HPV 16
438 (24.2)
129 (31.8)
278 (41)
43 (47.2)
HPV 18
113 (6.2)
33 (8.1)
68 (10.0)
10 (11)
HPV 31
223 (12.3)
66 (16.3)
133 (19.6)
9 (9.9)
HPV 33
62 (3.4)
26 (6.4)
40 (5.9)
3 (3.3)
HPV 35
42 (2.3)
10 (2.5)
21 (3.1)
1 (1.1)
HPV 39
116 (6.4)
19 (4.7)
48 (7.1)
9 (9.9)
HPV45
40 (2.2)
18 (4.4)
25 (3.7)
1 (1.1)
HPV 51
226 (12.5)
51 (12.6)
85 (12.5)
10 (11)
HPV 52
357 (19.7)
87 (21.5)
187 (27.6)
25 (27.5)
HPV 56
79 (4.4)
17 (4.)
32 (4.7)
7 (7.7)
HPV 58
55 (3.0)
19 (4.7)
23 (3.4)
2 (2.2)
HPV 66
123 (6.8)
28 (6.9)
32 (4.7)
11 (12.1)
Class of risk
Negative/undetermined/LR
HR single
508 (28.1)
57 (14.1)
58 (8.6)
7 (7.7)
HR multiple
849 (46.9)
212 (52.3)
328 (48.4)
51 (56)
454 (25.1)
136 (33.6)
292 (43.1)
33 (36.3)
compared to CIN 1, p for trend <05. IUD: intrauterine device; ASCUS: atypical squamous cells of undetermined significance; LSIL: low-grade squamous intraepithelial lesion; HSIL: high-grade squamous intraepithelial lesion; ASCH: atypical squamous cells cannot exclude high-grade intraepithelial lesion: AGUS: atypical glandular cells of undetermined significance; HPV: human papillomavirus; LR: low-risk; HR: high-risk.
