Clinical Significance of the Interaction between Human Papillomavirus (HPV) Type 16 and Other High-Risk Human Papillomaviruses in Women with Cervical Intraepithelial Neoplasia (CIN) and Invasive Cervical Cancer

Table 2

Significant interactions between HPV type 16 and other high-risk HPVs in a cohort of 2985 subjects with cervical intraepithelial neoplasia (CIN) or invasive cervical cancer.

Model coefficients
Predictor	Estimate	SE	Z		Rate ratio	95% confidence interval
						Lower	Upper
CIN 1
HPV16/HPV 52	-0.461	0.1505	3.06	0.002	0.6308	0.4697	0.8471
CIN 2 +
HPV 16/HPV 18	0.830	0.2019	4.11	<0.001	2.2926	0.4447	3.4057
HPV 16/HPV 31	−0.485	0.1658	2.93	0.003	0.6155	0.2847	0.8519
HPV 16/HPV 51	−0.849	0.2078	4.08	<0.001	0.4279	0.4953	0.6430
HPV 16/HPV 52	−0.423	0.1426	2.97	0.003	0.6551	0.1666	0.8663
HPV 16/HPV 53	−1.243	0.2803	4.43	<0.001	0.2886	0.1252	0.4999
HPV 16/HPV 66	−1.398	0.3467	4.03	<0.001	0.2470	0.1252	0.4873
Overall
HPV 16/HPV 18	0.683	0.1410	4.84	<0.001	1.9795	0.3494	2.6095
HPV 16/HPV 33	−0.609	0.2260	2.69	0.007	0.5441	0.5168	0.8474
HPV 16/HPV 51	−0.404	0.1306	3.10	0.002	0.6676	0.6295	0.8623
HPV 16/HPV 52	−0.255	0.1061	2.40	0.016	0.7751	0.3164	0.9542
HPV 16/HPV 66	−0.768	0.1954	3.93	<0.001	0.4641	1.5434	0.6808