Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells

Figure 1

Similarities and differences between glioblastoma cells versus astrocytes, glial progenitors, GFAP + NP (radial glia), and classical NSC. GB cells resemble GFAP + NP the most in terms of phenotype and susceptibility to senescence. Classical NSC and astrocytes do not show the expression of GFAP and SOX2, respectively. Although GFAP + NP radial glia and GB show similar differentiation features, GB differentiation is blocked. Astrocytes and glial progenitors differentiate in the same way as GB cells. Classical NSC, unlike GB cells, proliferate in vitro far beyond the limit. GFAP + NP and GB cells quickly become senescent in vitro.