Gaps and Doubts in Search to Recognize Glioblastoma Cellular Origin and Tumor Initiating Cells

Figure 3

GFAP + NP cells differentiate similarly to glioblastoma cells. However, GB cell differentiation appears to be blocked at the early stages. GFAP + NP radial glial cells also differentiate in a very distinctive way due to the presence of GFAP. The loss of GFAP is essential for NP to differentiate into neurons. GB cells exhibit similar differentiation characteristics but appear to be blocked at the early stages. GB cells, in contrast to NSC or GFAP + NP, can differentiate and dedifferentiate.

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