Genes Involved in the PD-L1 Pathway Might Associate with Radiosensitivity of Patients with Gastric Cancer

Table 1

Associations of clinical indicators and 13 genes expression levels with total survival.

	Univariate analysis		Multivariate analysis
	HR (95%CI)	values	HR (95%CI)	values
Radiotherapy
Yes	0.407 (0.255–0.651)	<0.001	0.417 (0.245–0.710)	0.001
No	1.0000		1.000
Gender
Male	1.271 (0.897–1.801)	0.178	1.308 (0.919–1.862)	0.136
Female	1.0000		1.000
Age
≥60	1.361 (0.945–1.96)	0.097	1.402 (0.958–2.053)	0.084
<60	1.0000		1.000
Histologic type
NOS	1.199 (0.788–1.823)	0.397	1.274 (0.831–1.954)	0.264
DT/MT/SRT	0.903 (0.555–1.47)	0.682	1.112 (0.682–1.840)	0.655
PT/TT	1.0000		1.000
T Stage
T3/T4	1.854 (1.215–2.827)	0.004	1.381 (0.855–2.230)	0.187
T1/T2	1.0000		1.000
M Stage
M1	1.909 (1.165–3.128)	0.010	1.674 (0.999–2.805)	0.050
M0	1.0000		1.000
N stage
N1/N2/N3	1.953 (1.301–2.931)	0.001	1.753 (1.023–3.004)	0.041
N0	1.0000		1.000
Pathological stage
III/IV	1.859 (1.309–2.639)	0.001	1.481 (0.897–2.446)	0.125
I/II	1.0000		1.000
Targeted therapy
Yes	0.680 (0.489–0.946)	0.022	0.894 (0.430–1.861)	0.765
No	1.0000		1.000
Chemotherapy
Yes	0.703 (0.508–0.973)	0.034	0.804 (0.401–1.610)	0.537
No	1.0000		1.000
CD274
High	0.813 (0.588–1.123)	0.209	0.734 (0.524–1.027)	0.071
Low	1.0000		1.000
EGFR
High	1.098 (0.794–1.518)	0.573	1.209 (0.867–1.686)	0.262
Low	1.0000		1.000
RAF1
High	1.046 (0.757–1.445)	0.786	1.249 (0.896–1.741)	0.190
Low	1.0000		1.000
MTOR
High	0.906 (0.656–1.252)	0.552	1.008 (0.725–1.401)	0.962
Low	1.0000		1.000
RPS6KB1
High	1.154 (0.836–1.595)	0.384	1.283 (0.920–1.789)	0.142
Low	1.0000		1.000
CHUK
High	0.865 (0.625–1.197)	0.382	0.941 (0.676–1.309)	0.717
Low	1.0000		1.000
NFKB1
High	0.873 (0.632–1.205)	0.409	1.016 (0.729–1.416)	0.926
Low	1.0000		1.000
TRAF6
High	1.268 (0.917–1.753)	0.151	1.358 (0.974–1.893)	0.071
Low	1.0000		1.000
FOS
High	1.124 (0.813–1.554)	0.478	1.287 (0.923–1.794)	0.137
Low	1.0000		1.000
HIF1A
High	1.256 (0.909–1.737)	0.168	1.184 (0.838–1.672)	0.339
Low	1.0000		1.000
NFATC1
High	1.291 (0.932–1.787)	0.124	1.364 (0.962–1.934)	0.081
Low	1.0000		1.000
PIK3CA
High	1.196 (0.864–1.656)	0.280	1.228 (0.876–1.722)	0.233
Low	1.0000		1.000
HRAS
High	0.881 (0.638–1.217)	0.441	0.882 (0.635–1.225)	0.454
Low	1.0000		1.000

Abbreviations.HR: hazard ratio; NOS: not otherwise specified; DT: diffuse type; MT: mucinous type; SRT: signet ring type; PT: papillary type; TT: tubular type.