Development of MicroRNAs as Potential Therapeutics against Cancer

Table 1

miRNAs as oncomiRs or tumor suppressors in cancers.

miRNAs	OncomiRs/tumor suppressor miRNAs	Cancer types	Function	References
miR-21	OncomiR	Lymphoma, breast, lung, colon, glioblastoma, pancreatic, ovarian, prostate, and gastric cancers	Promoted cell proliferation, metastasis, and invasion	[13–17]
miR-17-92 cluster	OncomiR	Lymphomas, lung cancer, colon cancer, and gastric cancer	Promoted angiogenesis and tumor growth	[18, 19]
miR-155	OncomiR	Lymphoma, lung, breast, and ovarian cancers	Promoted angiogenesis and tumor growth	[20–22]
miR-10b	OncomiR	Breast cancer, glioblastoma, and esophageal cancer	Promoted invasion and metastasis	[23–25]
miR-221/222	OncomiR	Lung cancer, hepatocellular carcinoma, breast cancer, gastric cancer, and glioblastoma	Promoted cell migration and proliferation	[26, 27]
Let-7	Tumor suppressor miRNA	Colon, breast, and lung cancers	Inhibited cell proliferation and regulated the cell cycle	[28, 29]
miR-34a	Tumor suppressor miRNA	Breast cancer, colon cancer, pancreatic cancer, and melanoma	Inhibited proliferation and invasion	[30–33]
miR-15a/16	Tumor suppressor miRNA	Leukemia and colorectal cancer	Promoted tumor growth	[34, 35]
miR-29	Tumor suppressor miRNA	Cervical cancer, breast cancer, and acute myeloid leukemia	Proliferation and metastasis	[36, 37]