AEBP1 is a Novel Oncogene: Mechanisms of Action and Signaling Pathways

Figure 1

An overview of the main regulatory effects of AEBP1 on cancer-related proteins and the major signaling pathways targeted by AEBP1 to promote its proproliferative, antiapoptotic, prometastatic, proangiogenic, and proinflammatory effects, triggering cancer development. AEBP1 protein possesses two well-characterized domains, a discoidin-like domain (DLD) at its N-terminus and a central carboxypeptidase (CP) domain. The C-terminus of AEBP1 contains three subdomains: a basic (B) subdomain, a serine-threonine-proline rich (STP) subdomain, and an acidic (A) subdomain.