Low Expression of DDX60 Gene Might Associate with the Radiosensitivity for Patients with Breast Cancer

Table 2

Associations of clinical indicators and DDX60 expression levels with total survival in validation data.

		Univariate analysis		Multivariate analysis
		HR (95% CI)	values	HR (95% CI)	values
Radiotherapy
Yes	210 (60.00%)	0.596 (0.320–1.108)	0.102	0.515 (0.221–1.200)	0.126
No	140 (40.00%)	1.000		1.000
Age
≥60	170 (48.57%)	2.296 (1.207–4.369)	0.011	2.593 (1.132–5.940)	0.025
<60	180 (51.43%)	1.000		1.000
History of other malignancies
Yes	22 (6.29%)	2.159 (0.760–6.131)	0.149	2.724 (0.767–9.676)	0.121
No	327 (93.43%)	1.000		1.000
NA	1 (0.29%)
Histologic type
IDC	229 (65.43%)	0.861 (0.397–1.866)	0.704	1.948 (0.732–5.184)	0.182
MBC	33 (9.43%)	1.509 (0.561–4.061)	0.416	3.344 (0.948–11.794)	0.061
ILC	82 (23.43%)	1.000		1.000
NA	6 (1.71%)
First surgical procedure
Lumpectomy	82 (23.43%)	1.570 (0.607–4.059)	0.352	1.392 (0.429–4.514)	0.582
Modified radical mastectomy	112 (32.00%)	1.159 (0.447–3.008)	0.761	1.070 (0.329–3.484)	0.911
Others	56 (16.00%)	0.498 (0.154–1.607)	0.243	0.413 (0.094–1.821)	0.248
A simple mastectomy	76 (21.71%)	1.000
NA	24 (6.86%)
T stage
T3/T4	57 (16.29%)	1.429 (0.694–2.942)	0.333	1.402 (0.555–3.543)	0.475
T1/T2	293 (83.71%)	1.000		1.000
N stage
N2/N3	66 (18.86%)	2.112 (0.982–4.539)	0.056	3.440 (1.066–11.099)	0.052
N0/N1	277 (79.14%)	1.000		1.000
NA	3 (2.00%)
M stage
M1	3 (0.86%)	14.508 (3.343–62.960)	<0.001	2.975 (0.685–12.920)	0.151
M0	297 (84.86%)	1.000		1.000
NA	50 (14.29%)
ER status by IHC
Positive	266 (76.00%)	0.726 (0.316–1.667)	0.450	1.193 (0.375–3.793)	0.765
Negative	61 (17.43%)	1.000		1.000
NA	23 (6.57%)
PR status by IHC
Positive	233 (66.57%)	0.6274 (0.321–1.227)	0.173	0.424 (0.146–1.232)	0.120
Negative	91 (26.00%)	1.000		1.000
NA	26 (7.43%)
HER2 status by IHC
Positive	63 (18.00%)	1.205 (0.468–3.107)	0.699	1.354 (0.402–4.561)	0.632
Overexpression	40 (11.43%)	1.281 (0.370–4.440)	0.696	0.934 (0.143–6.090)	0.944
Negative	192 (54.96%)	1.000		1.000
NA	55 (15.71%)
Chemotherapy
Yes	302 (86.29%)	0.678 (0.265–1.738)	0.419	0.517 (0.139–1.579)	0.247
No	47 (13.43%)	1.000		1.000
NA	1 (0.29%)
DDX60 expression
High	178 (50.86%)	0.590 (0.310–1.123)	0.108	0.527 (0.251–1.105)	0.090
Low	172 (49.14%)	1.000		1.000

Note. Abbreviations are the same as in Table 1.