Journal of Oncology / 2020 / Article / Tab 3

Research Article

Effects of BRCA Germline Mutations on Triple-Negative Breast Cancer Prognosis

Table 3

Therapy of 124 TNBC patients assessed for BRCA1/2 mutations.

Type of therapyPatients tested for BRCA mutations value (BRCA-positive vs BRCA-negative)
BRCA noncarriersRate (%)BRCA carriersRate (%)

Number of patients9410030100

Surgery
Yes909629970.7004
No4413

Type of surgery
Mastectomy60/9066.517/2958.50.2438
Breast-conserving surgery30/9033.512/2941.5

Radiotherapy
Yes5558.51756.50.7751
No3941.51343.5

Radiotherapy
After mastectomy27/55495/1729.50.0044
After breast-conserving surgery28/555112/1770.5

Neoadjuvant chemotherapy
Yes2021.5413.50.0940
No7478.52686.5

Regimens in neoadjuvant chemotherapy
AT⟶CMF5/20251/425<0.0001
Anthracycline + taxane9/20452/450
Anthracycline5/2051/425
Others1/202500

Adjuvant chemotherapy
Yes64682376.50.1541
No3032723.5

Regimens in adjuvant chemotherapy
Anthracycline (AC)41/646412/23520.0574
FEC/FAC11/6417.54/2317.5
Anthracycline + taxane8/6412.55/2321.5
CMF2/64300
Taxane2/6432/239

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.