Research Article

High Expression of COL17A1 Predicts Poor Prognosis and Promotes the Tumor Progression via NF-κB Pathway in Pancreatic Adenocarcinoma

Figure 3

Downregulation of COL17A1 inhibited proliferation and invasion in PDAC cells. The verification of si-COL17A1 downregulation was evaluated by RT-qPCR (a) and western blotting in AsPC-1 and HPAF-II cells (b, c). Effects of COL17A1 downregulation on proliferation and migration were done by wound healing (d)-(e) and CCK-8 (f, g) assays. (h, i) Transwell assay measured the COL17A1 downregulation effects on the invasion. Results shown are the mean ± SD (, , and ; the experiments were repeated at least three times). siRNA: transfected with small interfering RNAs.