High Expression of COL17A1 Predicts Poor Prognosis and Promotes the Tumor Progression via NF-κB Pathway in Pancreatic Adenocarcinoma

Table 3

Univariate and multivariate Cox regression analyses of prognostic characteristics for overall survival in PDAC patients.

Prognostic characteristics	Univariate analysis			Multivariate analysis
	p	HR	95% CI	p	HR	95% CI
Age	<0.05	1.517	1.008–2.282	<0.05	1.523	1.003–2.313
Gender	0.128	1.370	0.913–2.056	—	—	—
Clinical stage	<0.05	1.582	1.063–2.354	0.499	—	—
T classification	<0.01	2.281	1.327–3.921	0.081	—	—
N classification	0.068	1.448	0.973–2.156	0.444	—	—
Metastasis	<0.01	4.546	1.905–10.845	<0.05	2.477	1.014–6.053
Pathologic differentiation	0.916	1.023	0.666–1.573	0.626	—	—
Vascular invasion	0.077	1.504	0.957–2.364	—	—	—
Neural invasion	<0.001	2.252	1.492–3.400	<0.01	1.936	1.264–2.966
COL17A1	<0.01	2.201	1.394–3.475	<0.01	1.885	1.177–3.019

HR : hazard ratio; CI : confidence interval. The numbers in bold indicate that the p values are significant (, Cox regression method: forward LR).