Integrative Analysis Reveals the Landscape of Hypoxia-Inducible Factor (HIF) Family Genes in Pan-Cancer

Figure 1

Hypoxia-inducible factor family genes are widely dysregulated in human cancers. (a) The HIF genes are downregulated in a wide range of cancers. (b) Abnormal HIF gene expression associates with favorable or unfavorable patient survival in pan-cancer. FC: fold change, FDR: false discovery rate, THCA: thyroid carcinoma, KIRP: kidney renal papillary cell carcinoma, LIHC: liver hepatocellular carcinoma, STAD: stomach adenocarcinoma, BRCA: breast invasive carcinoma, COAD: colon adenocarcinoma, UCEC: uterine corpus endometrial carcinoma, BLCA: bladder urothelial carcinoma, KIRC: kidney renal clear cell carcinoma, KICH: kidney chromophobe, PRAD: prostate adenocarcinoma.

(a)

(b)