The Value of Alkaline Phosphatase-to-Albumin Ratio in Detecting Synchronous Metastases and Predicting Postoperative Relapses among Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms
Table 3
Cox analysis of predictors for recurrence-free survival in resected pNEN patients.
Characteristics
Univariate analysis
Multivariate analysis
HR (95% CI)
HR (95% CI)
Gender (male vs. female)
0.948 (0.289–3.109)
0.930
Age (>54 vs. ≤54 years)
2.651 (0.776–9.064)
0.120
Nonfunctioning (yes vs. no)
0.307 (0.039–2.397)
0.260
Location (body-tail vs. head-neck)
0.819 (0.237–2.834)
0.753
Diameter (>3.6 vs. ≤3.6 cm)
7.140 (1.893–26.930)
0.004
—
NS
Cystic component (yes vs. no)
0.039 (0.000–54.195)
0.379
No. of primary lesions (multiple vs. single)
2.256 (0.289–17.636)
0.438
Necrosis (yes vs. no)
—
0.705
Nerve invasion (yes vs. no)
6.058 (1.758–20.875)
0.004
3.939 (1.093–14.198)
0.036
Vascular invasion (yes vs. no)
1.605 (0.346–7.439)
0.546
Lymph node metastasis (yes vs. no)
13.137 (3.966–43.519)
<0.001
10.237 (2.956–35.456)
<0.001
Histological grade (G2 vs. G1)
11.057 (1.412–86.573)
0.022
—
NS
AJCC stage (III vs. I-II)
11.307 (3.431–37.269)
<0.001
—
NS
ALB (>41 vs. ≤41 g/L)
0.144 (0.018–1.127)
0.065
ALP (>79 vs. ≤79 U/L)
5.018 (1.530–16.454)
0.008
—
NS
APAR (>1.95 vs. ≤1.95)
5.192 (1.584–17.015)
0.007
—
NS
PNEN, pancreatic neuroendocrine neoplasm; AJCC, American Joint Committee on Cancer; ALB, albumin; ALP, alkaline phosphatase; APAR, alkaline phosphatase-to-albumin ratio; HR, hazard ratio; CI, confidence interval; NS, not significant.
