Journal of Oncology / 2020 / Article / Tab 3

Research Article

The Value of Alkaline Phosphatase-to-Albumin Ratio in Detecting Synchronous Metastases and Predicting Postoperative Relapses among Patients with Well-Differentiated Pancreatic Neuroendocrine Neoplasms

Table 3

Cox analysis of predictors for recurrence-free survival in resected pNEN patients.

CharacteristicsUnivariate analysisMultivariate analysis
HR (95% CI)HR (95% CI)

Gender (male vs. female)0.948 (0.289–3.109)0.930
Age (>54 vs. ≤54 years)2.651 (0.776–9.064)0.120
Nonfunctioning (yes vs. no)0.307 (0.039–2.397)0.260
Location (body-tail vs. head-neck)0.819 (0.237–2.834)0.753
Diameter (>3.6 vs. ≤3.6 cm)7.140 (1.893–26.930)0.004NS
Cystic component (yes vs. no)0.039 (0.000–54.195)0.379
No. of primary lesions (multiple vs. single)2.256 (0.289–17.636)0.438
Necrosis (yes vs. no)0.705
Nerve invasion (yes vs. no)6.058 (1.758–20.875)0.0043.939 (1.093–14.198)0.036
Vascular invasion (yes vs. no)1.605 (0.346–7.439)0.546
Lymph node metastasis (yes vs. no)13.137 (3.966–43.519)<0.00110.237 (2.956–35.456)<0.001
Histological grade (G2 vs. G1)11.057 (1.412–86.573)0.022NS
AJCC stage (III vs. I-II)11.307 (3.431–37.269)<0.001NS
ALB (>41 vs. ≤41 g/L)0.144 (0.018–1.127)0.065
ALP (>79 vs. ≤79 U/L)5.018 (1.530–16.454)0.008NS
APAR (>1.95 vs. ≤1.95)5.192 (1.584–17.015)0.007NS

PNEN, pancreatic neuroendocrine neoplasm; AJCC, American Joint Committee on Cancer; ALB, albumin; ALP, alkaline phosphatase; APAR, alkaline phosphatase-to-albumin ratio; HR, hazard ratio; CI, confidence interval; NS, not significant.

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