The DNMT1/miR-34a/FOXM1 Axis Contributes to Stemness of Liver Cancer Cells
The DNMT1/miR-34a/FoxM1 axis is a novel target for stemness in LCSLCs from SK-Hep-1 and Hep G2 cells. (a, b) DNMT1 activities and protein amounts in SK-Hep-1 cells or Hep G2 cells and the corresponding spheres (served as LCSLCs). (c) miR-34a-5p levels. (d) FoxM1 expression levels in SK-Hep-1 and Hep G2 cells as well as respective LCSLCs, with β-actin as an internal control. vs. corresponding parent cells (n = 3). (e, f) Sphere and colony formation rates in SK-Hep-1 and Hep G2 cells as well as respective LCSLCs. (g) CD44 expression levels in SK-Hep-1 cells and LCSLCs. vs. SK-Hep-1 cells (n = 3). (h) CD133 expression levels in Hep G2 cells and LCSLCs. vs. Hep G2 cells (n = 3). (i) Schematic diagram of DNMT1/miR-34a/FOXM1 axis-mediated mechanism of acquisition and maintenance of stemness in liver cancer.
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