Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer

Table 1

Correlation between genes expression of ADAMTS family and OS in gastric cancer patients of clinical stage.

ADAMTSs gene chip	Clinical stages I (n = 69); II (n = 145); III (n = 319); IV (n = 152)	HR (95% CI)	value	ADAMTSs RNA-seq	Clinical stages I (n = 50); II (n = 111); III (n = 149); IV (n = 38)	HR (95% CI)	value
ADAMTS1	I	1.95 (0.60–6.40)	0.26	ADAMTS1	I	1.08 (0.32–3.64)	0.90
	II	1.57 (0.83–2.97)	0.16		II	2.00 (0.98–4.05)	0.05
	III	1.11 (0.77–1.62)	0.57		III	1.12 (0.69–1.80)	0.65
	IV	1.52 (1.02–2.27)	0.04		IV	1.12 (0.49–2.56)	0.78
ADAMTS2	I	0.26 (0.07–0.96)	0.03	ADAMTS2	I	2.11 (0.61–7.25)	0.22
	II	0.62 (0.33–1.19)	0.15		II	1.62 (0.80–3.26)	0.17
	III	1.56 (1.07–2.28)	0.02		III	1.36 (0.84–2.19)	0.21
	IV	1.29 (0.87–1.91)	0.20		IV	1.28 (0.55–2.96)	0.57
ADAMTS3	I	1.18 (0.43–3.23)	0.75	ADAMTS3	I	0.60 (0.18–2.07)	0.42
	II	1.52 (0.83–2.76)	0.17		II	1.26 (0.63–2.51)	0.51
	III	1.13 (0.85–1.5)	0.40		III	1.35 (0.83–2.18)	0.22
	IV	1.46 (1.00–2.15)	0.05		IV	1.12 (0.48–2.58)	0.80
ADAMTS4(none)	—			ADAMTS4	I	1.42 (0.41–4.91)	0.57
					II	2.04 (0.99–4.19)	0.05
					III	1.24 (0.76–2.01)	0.39
					IV	1.20 (0.52–2.78)	0.67
ADAMTS5	I	0.48 (0.16–1.49)	0.19	ADAMTS5	I	0.69 (0.22–2.16)	0.52
	II	1.66 (0.86–3.18)	0.13		II	1.20 (0.61–2.36)	0.61
	III	1.81 (1.24–2.64)	<0.01		III	1.44 (0.89–2.33)	0.14
	IV	1.51 (1.02–2.25)	0.04		IV	1.32 (0.57–3.08)	0.51
ADAMTS6	I	0.41 (0.12–1.33)	0.12	ADAMTS6	I	1.15 (0.36–3.65)	0.81
	II	1.40 (0.74–2.63)	0.29		II	1.50 (0.75–3.00)	0.25
	III	1.36 (0.93–1.98)	0.11		III	1.68 (1.04–2.72)	0.03
	IV	1.31 (0.88–1.95)	0.18		IV	3.37 (1.30–8.69)	<0.01
ADAMTS7	I	2.56 (0.77–8.56)	0.11	ADAMTS7	I	2.82 (0.75–10.63)	0.11
	II	1.35 (0.71–2.57)	0.35		II	1.10 (0.55–2.17)	0.79
	III	1.77 (1.21–2.57)	<0.01		III	1.44 (0.89–2.33)	0.14
	IV	1.76 (1.18–2.63)	<0.01		IV	1.19 (0.51–2.76)	0.68
ADAMTS8	I	1.87 (0.56–6.23)	0.30	ADAMTS8	I	1.89 (0.57–6.32)	0.29
	II	1.52 (0.80–2.88)	0.19		II	1.16 (0.59–2.28)	0.66
	III	1.2 (0.82–1.74)	0.34		III	1.55 (0.96–2.52)	0.07
	IV	1.4 (0.94–2.09)	0.10		IV	1.13 (0.49–2.59)	0.77
ADAMTS9	I	0.86 (0.29–2.57)	0.78	ADAMTS9	I	1.11 (0.34–3.65)	0.87
	II	1.39 (0.74–2.61)	0.31		II	1.08 (0.55–2.13)	0.82
	III	1.36 (0.94–1.98)	0.10		III	1.22 (0.75–1.99)	0.41
	IV	1.58 (1.06–2.34)	0.02		IV	1.35 (0.58–3.12)	0.49
ADAMTS10	I	2.12 (0.69–6.48)	0.18	ADAMTS10	I	1.10 (0.33–3.62)	0.88
	II	0.89 (0.48–1.65)	0.71		II	1.72 (0.86–3.43)	0.12
	III	1.15 (0.79–1.67)	0.47		III	1.25 (0.77–2.02)	0.37
	IV	0.76 (0.51–1.13)	0.17		IV	1.46 (0.63–3.39)	0.38
ADAMTS12	I	1.06 (0.40–2.84)	0.91	ADAMTS12	I	1.41 (0.45–4.44)	0.56
	II	1.67 (0.92–3.05)	0.09		II	1.72 (0.85–3.46)	0.12
	III	1.33 (1.00–1.77)	0.05		III	1.43 (0.89–2.32)	0.14
	IV	1.13 (0.77–1.65)	0.54		IV	1.57 (0.67–3.66)	0.29
ADAMTS13	I	1.75 (0.57–5.37)	0.32	ADAMTS13	I	0.39 (0.12–1.31)	0.11
	II	1.33 (0.71–2.49)	0.37		II	0.99 (0.50–1.94)	0.97
	III	1.11 (0.77–1.62)	0.57		III	0.91 (0.56–1.46)	0.69
	IV	0.86 (0.58–1.28)	0.47		IV	0.88 (0.39–2.01)	0.76
ADAMTS14	I	0.83 (0.26–2.67)	0.75	ADAMTS14	I	0.66 (0.21–2.09)	0.47
	II	1.19 (0.62–2.25)	0.60		II	0.76 (0.38–1.49)	0.42
	III	1.42 (0.98–2.07)	0.06		III	1.36 (0.84–2.20)	0.21
	IV	2.10 (1.40–3.16)	<0.01		IV	0.96 (0.42–2.23)	0.93
ADAMTS15	I	1.13 (0.38–3.39)	0.82	ADAMTS15	I	0.69 (0.21–2.26)	0.54
	II	1.33 (0.71–2.49)	0.36		II	2.14 (1.05–4.35)	0.03
	III	1.10 (0.76–1.60)	0.62		III	1.32 (0.82–2.13)	0.26
	IV	1.31 (0.89–1.95)	0.17		IV	1.78 (0.76–4.17)	0.18
ADAMTS16	I	1.25 (0.42–3.73)	0.69	ADAMTS16	I	1.10 (0.35–3.50)	0.87
	II	1.00 (0.53–1.87)	0.99		II	2.60 (1.26–5.36)	<0.01
	III	1.06 (0.73–1.54)	0.76		III	1.13 (0.70–1.81)	0.62
	IV	1.20 (0.81–1.77)	0.37		IV	1.66 (0.71–3.88)	0.24
ADAMTS17	I	0.89 (0.29–2.70)	0.84	ADAMTS17	I	1.22 (0.38–3.87)	0.74
	II	1.88 (0.99–3.58)	0.05		II	0.53 (0.26–1.08)	0.08
	III	1.17 (0.81–1.70)	0.40		III	0.71 (0.44–1.14)	0.16
	IV	0.97 (0.65–1.43)	0.86		IV	1.58 (0.69–3.64)	0.27
ADAMTS18	I	1.32 (0.42–4.16)	0.64	ADAMTS18	I	2.51 (0.75–8.42)	0.12
	II	2.35 (1.20–4.59)	0.01		II	2.41 (1.18–4.82)	0.01
	III	1.06 (0.73–1.55)	0.74		III	1.49 (0.92–2.41)	0.11
	IV	1.22 (0.82–1.81)	0.32		IV	1.00 (0.43–2.33)	1.00
ADAMTS19	I	3.17 (0.97–10.37)	0.05	ADAMTS19	I	4.89 (1.32–18.14)	<0.01
	II	1.07 (0.57–2.01)	0.82		II	0.52 (0.26–1.06)	0.07
	III	1.06 (0.73–1.54)	0.74		III	1.30 (0.80–2.09)	0.29
	IV	0.97 (0.65–1.44)	0.88		IV	1.52 (0.65–3.52)	0.33
ADAMTS20	I	1.56 (0.55–4.37)	0.40	ADAMTS20	I	1.58 (0.48–5.21)	0.45
	II	1.36 (0.75–2.46)	0.31		II	1.44 (0.73–2.85)	0.29
	III	1.42 (1.07–1.89)	0.02		III	0.87 (0.54–1.41)	0.58
	IV	1.25 (0.85–1.82)	0.26		IV	1.04 (0.44–2.45)	0.92