Prognostic Values for the mRNA Expression of the ADAMTS Family of Genes in Gastric Cancer

Table 2

Correlation between genes expression of ADAMTS family and OS in gastric cancer patients of differentiation.

ADAMTSs gene chip	Differentiation poorly (n = 166); moderately (n = 67); well (n = 32)	HR (95% CI)	value	ADAMTSs RNA-seq	Differentiation I (n = 12); II (n = 134); III (n = 218)	HR (95% CI)	value
ADAMTS1	Poorly differentiated	0.85 (0.57–1.27)	0.43	ADAMTS1	Grade I	1.29 × 109 (0–inf)	0.23
	Moderately differentiated	0.96 (0.50–1.83)	0.90		Grade II	1.26 (0.72–2.20)	0.43
	Well differentiated	—			Grade III	1.37 (0.91–2.07)	0.13
ADAMTS2	Poorly differentiated	1.17 (0.78–1.74)	0.45	ADAMTS2	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	1.31 (0.69–2.52)	0.41		Grade II	1.35 (0.76–2.37)	0.30
	Well differentiated	—			Grade III	1.30 (0.86–1.97)	0.21
ADAMTS3	Poorly differentiated	1.23 (0.82–1.83)	0.32	ADAMTS3	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	1.35 (0.71–2.59)	0.36		Grade II	0.79 (0.45–1.40)	0.43
	Well differentiated	1.52 (0.64–3.61)	0.34		Grade III	1.33 (0.88–2.01)	0.17
ADAMTS5	Poorly differentiated	1.16 (0.72–1.88)	0.54	ADAMTS5	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	0.96 (0.50–1.84)	0.91		Grade II	0.98 (0.56–1.73)	0.95
	Well differentiated	—			Grade III	1.26 (0.83–1.91)	0.27
ADAMTS6	Poorly differentiated	1.07 (0.66–1.73)	0.78	ADAMTS6	Grade I	3.9 × 109 (0-inf)	0.44
	Moderately differentiated	1.49 (0.78–2.84)	0.23		Grade II	1.45 (0.81–2.58)	0.20
	Well differentiated	—			Grade III	1.93 (1.27–2.93)	<0.01
ADAMTS7	Poorly differentiated	0.97 (0.65–1.44)	0.86	ADAMTS7	Grade I	1.41 (0.08–23.57)	0.81
	Moderately differentiated	2.39 (1.24–4.59)	<0.01		Grade II	1.12 (0.63–1.99)	0.69
	Well differentiated	—			Grade III	1.58 (1.03–2.41)	0.04
ADAMTS8	Poorly differentiated	1.10 (0.68–1.79)	0.69	ADAMTS8	Grade I	3.56 × 109 (0-inf)	0.06
	Moderately differentiated	1.43 (0.75–2.74)	0.28		Grade II	1.00 (0.57–1.75)	0.99
	Well differentiated	—			Grade III	1.07 (0.71–1.61)	0.76
ADAMTS9	Poorly differentiated	1.07 (0.66–1.74)	0.77	ADAMTS9	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	1.34 (0.70–2.55)	0.38		Grade II	0.85 (0.48–1.49)	0.57
	Well differentiated	—			Grade III	1.50 (0.98–2.29)	0.06
ADAMTS10	Poorly differentiated	1.08 (0.67–1.74)	0.76	ADAMTS10	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	0.81 (0.42–1.55)	0.52		Grade II	1.31 (0.75–2.30)	0.35
	Well differentiated	–			Grade III	1.41 (0.93–2.14)	0.10
ADAMTS12	Poorly differentiated	1.30 (0.87–1.94)	0.21	ADAMTS12	Grade I	0.71 (0.04–11.79)	0.81
	Moderately differentiated	1.00 (0.52–1.92)	0.99		Grade II	1.50 (0.85–2.66)	0.16
	Well differentiated	0.95 (0.40–2.23)	0.90		Grade III	1.54 (1.02–2.34)	0.04
ADAMTS13	Poorly differentiated	0.87 (0.54–1.41)	0.58	ADAMTS13	Grade I	1.62 × 109 (0-inf)	0.32
	Moderately differentiated	1.06 (0.55–2.04)	0.87		Grade II	0.46 (0.25–0.85)	0.01
	Well differentiated	—			Grade III	0.88 (0.59–1.33)	0.56
ADAMTS14	Poorly differentiated	1.28 (0.78–2.08)	0.32	ADAMTS14	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	1.80 (0.93–3.47)	0.08		Grade II	0.81 (0.46–1.44)	0.48
	Well differentiated	—			Grade III	0.99 (0.66–1.49)	0.95
ADAMTS15	Poorly differentiated	0.97 (0.59–1.59)	0.91	ADAMTS15	Grade I	2.60 × 109 (0-inf)	0.09
	Moderately differentiated	1.34 (0.69–2.59)	0.38		Grade II	1.23 (0.70–2.17)	0.47
	Well differentiated	—			Grade III	1.59 (1.05–2.41)	0.03
ADAMTS16	Poorly differentiated	0.69 (0.42–1.14)	0.14	ADAMTS16	Grade I	0.71 (0.04–11.79)	0.81
	Moderately differentiated	1.43 (0.75–2.73)	0.28		Grade II	0.95 (0.54–1.68)	0.86
	Well differentiated	—			Grade III	1.56 (1.03–2.36)	0.03
ADAMTS17	Poorly differentiated	0.95 (0.59–1.53)	0.83	ADAMTS17	Grade I	1.41 (0.08–23.57)	0.81
	Moderately differentiated	1.14 (0.59–2.18)	0.70		Grade II	0.98 (0.55–1.74)	0.93
	Well differentiated	—			Grade III	0.77 (0.51–1.17)	0.22
ADAMTS18	Poorly differentiated	1.18 (0.73–1.91)	0.50	ADAMTS18	Grade I	1.29 × 109 (0-inf)	0.23
	Moderately differentiated	1.27 (0.66–2.43)	0.47		Grade II	1.27 (0.72–2.24)	0.41
	Well differentiated	—			Grade III	1.84 (1.20–2.83)	<0.01
ADAMTS19	Poorly differentiated	0.79 (0.49–1.28)	0.34	ADAMTS19	Grade I	1.86 × 109 (0-inf)	0.16
	Moderately differentiated	1.25 (0.65–2.38)	0.50		Grade II	1.12 (0.63–1.98)	0.71
	Well differentiated	—			Grade III	1.20 (0.79–1.81)	0.39
ADAMTS20	Poorly differentiated	1.10 (0.74–1.64)	0.63	ADAMTS20	Grade I	0 (0-inf)	0.09
	Moderately differentiated	0.95 (0.5–1.82)	0.88		Grade II	1.21 (0.68–2.15)	0.52
	Well differentiated	1.92 (0.81–4.57)	0.13		Grade III	1.20 (0.80–1.81)	0.38