Research Article
Upregulation of Nei-Like DNA Glycosylase 3 Predicts Poor Prognosis in Hepatocellular Carcinoma
Table 2
Univariate and multivariate analyses of prognostic factors of OS.
| Factors | Univariate analysis | Multivariate analysis | HR (95% CI) | value | HR (95% CI) | value |
| NEIL3 (high vs. low) | 2.368 (1.414–3.968) | 0.001 | 1.980 (1.159–3.380) | 0.012 | TNM (III–IV vs. I–II) | 3.257 (1.982–5.352) | <0.001 | 10.529 (1.399–79.261) | 0.022 | AFP (ng/mL) (>20 vs. ≤20) | 2.550(1.410–4.614) | 0.002 | 1.967 (1.073–3.605) | 0.029 | Tumor size (cm) (>5 vs. ≤5) | 2.571 (1.531–4.312) | <0.001 | 2.171 (1.242–3.796) | 0.007 | Tumor differentiation (III–IV vs. I–II) | 2.710 (1.649–4.451) | <0.001 | 2.032 (1.223–3.376) | 0.006 | BCLC (0-A vs. B-C) | 2.012 (1.231–3.286) | 0.005 | 0.164 (0.022–1.233) | 0.079 | Tumor number (multiple vs. solitary) | 1.032 (0.614–1.736) | 0.905 | — | n.a. | Gender (male vs. female) | 0.890 (0.500–1.584) | 0.691 | — | n.a. | Age, years (≥55 vs. <55) | 0.803 (0.474–1.360) | 0.415 | — | n.a. | HBsAg (positive vs. negative) | 1.115 (0.583–2.133) | 0.742 | — | n.a. | Cirrhosis (positive vs. negative) | 0.897 (0.479–1.679) | 0.734 | — | n.a. |
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NEIL3, Nei-like DNA glycosylase 3; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; TNM, tumor-nodes-metastasis; ; BCLC, Barcelona Clinic Liver Cancer; AFP, serum alpha-fetoprotein; HBsAg, hepatitis B surface antigen; n.a., not applicable. Bold values represent P < 0.05, which is statistically significant.
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