Upregulation of Nei-Like DNA Glycosylase 3 Predicts Poor Prognosis in Hepatocellular Carcinoma

Table 2

Univariate and multivariate analyses of prognostic factors of OS.

Factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
NEIL3 (high vs. low)	2.368 (1.414–3.968)	0.001	1.980 (1.159–3.380)	0.012
TNM (III–IV vs. I–II)	3.257 (1.982–5.352)	<0.001	10.529 (1.399–79.261)	0.022
AFP (ng/mL) (>20 vs. ≤20)	2.550(1.410–4.614)	0.002	1.967 (1.073–3.605)	0.029
Tumor size (cm) (>5 vs. ≤5)	2.571 (1.531–4.312)	<0.001	2.171 (1.242–3.796)	0.007
Tumor differentiation (III–IV vs. I–II)	2.710 (1.649–4.451)	<0.001	2.032 (1.223–3.376)	0.006
BCLC (0-A vs. B-C)	2.012 (1.231–3.286)	0.005	0.164 (0.022–1.233)	0.079
Tumor number (multiple vs. solitary)	1.032 (0.614–1.736)	0.905	—	n.a.
Gender (male vs. female)	0.890 (0.500–1.584)	0.691	—	n.a.
Age, years (≥55 vs. <55)	0.803 (0.474–1.360)	0.415	—	n.a.
HBsAg (positive vs. negative)	1.115 (0.583–2.133)	0.742	—	n.a.
Cirrhosis (positive vs. negative)	0.897 (0.479–1.679)	0.734	—	n.a.

NEIL3, Nei-like DNA glycosylase 3; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; TNM, tumor-nodes-metastasis; ; BCLC, Barcelona Clinic Liver Cancer; AFP, serum alpha-fetoprotein; HBsAg, hepatitis B surface antigen; n.a., not applicable. Bold values represent P < 0.05, which is statistically significant.