Upregulation of Nei-Like DNA Glycosylase 3 Predicts Poor Prognosis in Hepatocellular Carcinoma

Table 3

Univariate and multivariate analyses of prognostic factors of DFS.

Factors	Univariate analysis		Multivariate analysis
	HR (95% CI)	value	HR (95% CI)	value
NEIL3 (high vs. low)	2.172 (1.392–2.390)	0.001	1.947 (1.233–3.074)	0.004
TNM (III–IV vs. I–II)	2.873 (1.826–4.520)	<0.001	3.131 (1.165–8.416)	0.024
Tumor differentiation (III–IV vs. I–II)	1.970 (1.284–3.022)	0.002	1.691 (1.089–2.625)	0.019
Tumor size, cm (>5 vs. ≤5)	1.745 (1.135–2.683)	0.011	1.403 (0.866–2.273)	0.169
AFP, ng/mL (>20 vs. ≤20)	1.864 (1.160–2.995)	0.010	1.443 (0.887–2.349)	0.140
BCLC (0-A vs. B-C)	1.948 (1.263–3.004)	0.003	0.628 (0.236–1.669)	0.350
Tumor number (multiple vs. solitary)	1.131 (0.719–1.779)	0.596	—	n.a.
Gender (male vs. female)	1.043 (0.620–1.756)	0.874	—	n.a.
Age, years (≥55 vs. <55)	0.888 (0.564–1.396)	0.606	—	n.a.
HBsAg (positive vs. negative)	1.044 (0.597–1.823)	0.881	—	n.a.
Cirrhosis (positive vs. negative)	1.045 (0.589–1.854)	0.881	—	n.a.

NEIL3, Nei-like DNA glycosylase 3; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; TNM, tumor-nodes-metastasis; BCLC, Barcelona Clinic Liver Cancer; AFP, serum alpha-fetoprotein; HBsAg, hepatitis B surface antigen; n.a., not applicable.