Research Article
Upregulation of Nei-Like DNA Glycosylase 3 Predicts Poor Prognosis in Hepatocellular Carcinoma
Table 3
Univariate and multivariate analyses of prognostic factors of DFS.
| Factors | Univariate analysis | Multivariate analysis | HR (95% CI) | value | HR (95% CI) | value |
| NEIL3 (high vs. low) | 2.172 (1.392–2.390) | 0.001 | 1.947 (1.233–3.074) | 0.004 | TNM (III–IV vs. I–II) | 2.873 (1.826–4.520) | <0.001 | 3.131 (1.165–8.416) | 0.024 | Tumor differentiation (III–IV vs. I–II) | 1.970 (1.284–3.022) | 0.002 | 1.691 (1.089–2.625) | 0.019 | Tumor size, cm (>5 vs. ≤5) | 1.745 (1.135–2.683) | 0.011 | 1.403 (0.866–2.273) | 0.169 | AFP, ng/mL (>20 vs. ≤20) | 1.864 (1.160–2.995) | 0.010 | 1.443 (0.887–2.349) | 0.140 | BCLC (0-A vs. B-C) | 1.948 (1.263–3.004) | 0.003 | 0.628 (0.236–1.669) | 0.350 | Tumor number (multiple vs. solitary) | 1.131 (0.719–1.779) | 0.596 | — | n.a. | Gender (male vs. female) | 1.043 (0.620–1.756) | 0.874 | — | n.a. | Age, years (≥55 vs. <55) | 0.888 (0.564–1.396) | 0.606 | — | n.a. | HBsAg (positive vs. negative) | 1.044 (0.597–1.823) | 0.881 | — | n.a. | Cirrhosis (positive vs. negative) | 1.045 (0.589–1.854) | 0.881 | — | n.a. |
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NEIL3, Nei-like DNA glycosylase 3; HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; TNM, tumor-nodes-metastasis; BCLC, Barcelona Clinic Liver Cancer; AFP, serum alpha-fetoprotein; HBsAg, hepatitis B surface antigen; n.a., not applicable.
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