Research Article
ZC3H13 Inhibits the Progression of Hepatocellular Carcinoma through m6A-PKM2-Mediated Glycolysis and Enhances Chemosensitivity
Figure 7
PKM2 knockdown weakens cell proliferation and metabolic reprogramming mediated by ZC3H13 in HCC cells. (a) RT-qPCR detecting the mRNA expression of PKM2 for Hep3B as well as HUH-7 cells transfected by siRNAs against PKM2. (b, c) CCK-8 examining the effects of PKM2 knockdown on cell growth for Hep3B as well as HUH-7 cells with ZC3H13 loss. (d, e) The effects of silencing or overexpressing PKM2 on clone formation of Hep3B as well as HUH-7 cells with ZC3H13 knockdown. (f, g) The effects of PKM2 knockdown on glucose uptake and lactate production in Hep3B and HUH-7 cells with ZC3H13 deficiency.; .
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