Survivin Regulates Bad Gene Expression by Binding to Its Promoter and Modulates Cell Cycle and Apoptosis in Esophageal Carcinoma Cell

Figure 2

The effects of survivin overexpression and knockdown on the cell cycle progression of esophageal carcinoma cell. (a) The UP groups exhibited a decreased number of cells in the G2 phase but an increased number of cells in the S phases in KYSE450 cells. (b) The UP groups exhibited a decreased number of cells in the G2 phase but an increased number of cells in the S phases in ECA109 cells. (c) The KD groups exhibited an increased number of cells in the G2 phase but a decreased number of cells in the S phases in KYSE450 cells. (d) The KD groups exhibited an increased number of cells in the G2 phase, but a decreased number of cells in the S phases in ECA109 cells. Data are presented as the means ± standard deviation from triplicate experiments. BC: blank control; NC, UP, and KD: cells in these groups were transfected with negative control, overexpression, and shRNA plasmid, respectively. Statistically significant differences compared to BC and NC groups are indicated ( < 0.05,  < 0.01).

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