Survivin Regulates Bad Gene Expression by Binding to Its Promoter and Modulates Cell Cycle and Apoptosis in Esophageal Carcinoma Cell

Figure 3

The effects of survivin overexpression and knockdown on the apoptosis of esophageal carcinoma cell. (a) There was not significantly alteration of apoptotic rate among UP, BC, and NC groups both in KYSE450 and ECA109 cells. (b) Apoptotic rate of the KD group was significantly higher compared with the BC and NC groups. Data are presented as the means ± standard deviation from triplicate experiments. BC: blank control; NC, UP, and KD: cells in these groups were transfected with negative control, overexpression, and shRNA plasmid, respectively. Statistically significant differences compared to BC and NC groups are indicated ( < 0.05,  < 0.01).

(a)

(b)