Optimal Strategy for Colorectal Cancer Patients’ Diagnosis Based on Circulating Tumor Cells and Circulating Tumor Endothelial Cells by Subtraction Enrichment and Immunostaining-Fluorescence In Situ Hybridization Combining with CEA and CA19-9

Table 1

Clinicopathological characteristics of CRC patients and results of CTCs and CTECs.

Characteristics	Total (N = 115)	CTCs		value	CTECs		value
		Positive (N = 101)	Negative (N = 14)		Positive (N = 45)	Negative (N = 70)
Gender				0.415			0.435
Male	69	62	7		29	40
Female	46	39	7		16	30
Age				0.754			0.102
≤60	62	55	7		20	42
>60	53	46	7		25	28
Location				0.333			0.572
Colon	60	51	9		22	38
Rectum	55	50	5		23	32
Differentiation				0.148			0.364
Poor	13	10	3		3	10
Moderate/well	98	89	9		40	58
Unknown	4	2	2		2	2
Stage				0.006			0.010
I-II	25	18	7		4	21
III-IV	90	83	7		41	49
Distant metastasis				0.091			0.186
Yes	50	47	3		23	27
No	65	54	11		22	43
Lymph node metastasis				0.014			0.016
Yes	78	73	5		37	41
No	28	21	7		6	22
Unknown	9	7	2		2	7