SLCO4A1-AS1 Facilitates the Malignant Phenotype via miR-149-5p/STAT3 Axis in Gastric Cancer Cells

Figure 1

Highly expressed SLCO4A1-AS1 was detected in gastric cancer and regulated cell viability. (a) The starBase database (http://starbase.sysu.edu.cn/) analyzed the differential expression of SLCO4A1-AS1 in stomach adenocarcinoma (STAD) patients (n = 375) and normal samples (n = 32, ). (b, c) SLCO4A1-AS1 was highly expressed in gastric cancer tissues (n = 46) and cell lines, detected by RT-qPCR. (d, e) RT-qPCR was used to detect the level of SLCO4A1-AS1 after exogenous overexpression or intervention. (f, g) Overexpression of SLCO4A1-AS1 promoted SNU-16 cell viability, while silencing SLCO4A1-AS1 inhibited AGS cell viability, as determined by CCK-8. GAPDH was set as control. Each experiment was repeated three times independently. SLCO4A1-AS1: SLCO4A1 antisense RNA 1; RT-qPCR: Real-Time Quantitative PCR; CCK-8: Cell Counting Kit-8; ^{^^} versus adjacent tissue; ^△△ versus GES-1; ^∗ and ^∗∗ versus pc-control; ^# and ^## versus si-control.

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