SLCO4A1-AS1 Facilitates the Malignant Phenotype via miR-149-5p/STAT3 Axis in Gastric Cancer Cells

Figure 5

Effects of SLCO4A1-AS1/miR-149-5p axis on migration and invasion of gastric cancer cells. (a–d) miR-149-5p mimic inhibited cell migration, inhibitor was the opposite, and miR-149-5p partially reversed the effect of SLCO4A1-AS1. The results were analyzed by wound healing experiments (magnification ×100). (e, f) Invasion of SNU-16 cells in control, mimic-control, mimic, mimic + pc-SLCO4A1-AS1, and pc-SLCO4A1-AS1 groups was determined by Transwell (magnification ×200). (g, h) Invasion of AGS cells in control, inhibitor-control, inhibitor, inhibitor + si-SLCO4A1-AS1, and si-SLCO4A1-AS1 groups was measured by Transwell (magnification ×200). Each experiment was repeated three times independently. ^∗ and ^∗∗ versus mimic-control; ^& and ^&& versus mimic; ^△△ versus pc-SLCO4A1-AS1; ^{^} and ^{^^} versus control; ^# and ^## versus inhibitor-control; ^§ and ^§§ versus inhibitor; ^‡ and ^‡‡ versus si-SLCO4A1-AS1.

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