| | Variables | Item | Univariate | Multivariate | | HR | 95% CI | value | HR | 95% CI | value |
| | Age (y) | >70 | 1.62 | (0.79, 3.30) | 0.188 | 2.37 | (0.98, 5.73) | 0.056 | | ≤70 | 1.00 | | | 1.00 | | |
| | Sex | Male | 1.50 | (0.70, 3.21) | 0.295 | 0.74 | (0.26, 2.11) | 0.576 | | Female | 1.00 | | | 1.00 | | |
| | Grade | II/III | 1.82 | (0.70, 4.68) | 0.218 | 1.05 | (0.33, 3.33) | 0.928 | | I | 1.00 | | | 1.00 | | |
| | T status | T4/T3 | 1.44 | (0.65, 3.18) | 0.364 | 1.81 | (0.72, 4.52) | 0.205 | | T2/T1 | 1.00 | | | 1.00 | | |
| | N status | Positive | 3.43 | (1.64, 7.19) | 0.001 | 3.26 | (1.42, 7.48) | 0.005 | | Negative | 1.00 | | | 1.00 | | |
| | M status | Positive | 3.35 | (1.59, 7.08) | 0.002 | 1.24 | (0.42, 3.73) | 0.697 | | Negative | 1.00 | | | 1.00 | | |
| | Histology | Squamous cell carcinoma | 2.72 | (1.36, 5.44) | 0.005 | 3.98 | (1.59, 9.94) | 0.003 | | Adenocarcinoma | 1.00 | | | 1.00 | | |
| | Performance | 1 | 4.55 | (2.28, 9.07) | <0.001 | 5.34 | (2.24, 12.73) | <0.001 | | 0 | 1.00 | | | 1.00 | | |
| | Smoking status | Current | 2.54 | (1.19, 5.41) | 0.016 | 1.71 | (0.56, 5.21) | 0.345 | | Former | 1.89 | (0.79, 4.52) | 0.152 | 2.09 | (0.70, 6.26) | 0.187 | | Never | 1.00 | | | 1.00 | | |
| | HTR3C | High | 5.69 | (2.20, 14.73) | <0.001 | 8.38 | (2.93, 23.98) | <0.001 | | Low | 1.00 | | | 1.00 | | |
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