DNA Methylation Modification Regulator-Mediated Molecular Clusters and Tumor Metabolic Characterization in Prostate Cancer

Figure 1

Multiomics landscape of DMM regulators in PCa. (a) Overview of the 20 DMM regulators and their major biological functions. (b) Boxplot shows the expression of 20 DMM regulators between tumor and normal tissues in the TCGAPRAD cohort. (c) The mutation frequency of 20 DMM regulators in TCGA PRAD cohort. Each column of the figure represents an individual patient. The upper bar plot represents TMB. The number on the right shows the mutation frequency of each regulator. The right bar plot indicates the proportion of each variant type. (d) The CNV frequency of DNA methylation regulators in TCGA PRAD cohort. (e) Boxplot shows the DNA methylation level of 20 DMM regulators between tumor and normal tissues in the TCGAPRAD cohort. (f) Correlations and prognosis of DMM regulators in PCa patients in TCGA PRAD cohort. The red line represents a positive correlation with , and the blue line represents a negative correlation with . The size of the node represents the value of the log-rank test. Orange points represent favorable factors for DFS. Blue points represent risk factors for DFS. , , and .

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