Genetic Polymorphism rs6505162 in MicroRNA-423 May Not Be Associated with Susceptibility of Breast Cancer: A Systematic Review and Meta-Analysis

Table 1

Characteristics of studies included in the meta-analysis.

First author	Year	Ethnicity	Country	Cancer type	Testing method	NOS score	for HWE	Control source	Sample size (n)		Matched parameters
									Cases	Controls
Kontorovich et al. [17]	2010	Caucasian	Israel	BRCA1, BRCA2	iPLEX	6	0.899	PB	190	206	Undetermined
Smith et al. [18]	2012	Caucasian	Australia	—	HRM	7	0.307	HB	179	174	Age, sex, ethnicity
Ma et al. [19]	2013	Asian	China	TNBC	MassArray	7	0.847	HB	192	189	Age, sex, ethnicity, smoking status
He et al. [20]	2015	Asian	China	—	MassArray	8	0.103	PB	450	450	Age, menopausal status
Zhang et al. [21]	2015	Asian	China	—	MassArray	8	0.847	PB	382	189	Age, smoking status
Zhao et al. [22]	2015	Asian	China	—	Sequencing	6	0.847	PB	114	189	Undetermined
Morales et al. [7]	2016	Caucasian	Chile	—	TaqMan	6	0.700	HB	440	807	Age, socioeconomic strata
Saedi et al. [23]	2017	Asian	Iran	—	PCR-RFLP	6	0.196	HB	353	353	Undetermined
Tran Thi et al. [24]	2018	Asian	Vietnam	—	HRM	6	0.071	PB	106	116	Undetermined
Mir et al. [25]	2018	Asian	Saudi Arabia	—	ARMS-PCR	7	<0.001	PB	124	100	Sex
Mir et al. [26]	2019	Asian	Saudi Arabia	—	ARMS-PCR	7	0.152	PB	30	30	Sex
Pourmoshir et al. [27]	2020	Asian	Iran	—	ARMS-PCR	7	0.206	PB	153	153	Sex

Abbreviations: BRCA1, breast cancer type 1 susceptibility gene; BRCA2, breast cancer type 2 susceptibility gene; TNBC, triple-negative breast cancer; HB, hospital-based source of control; PB, population-based source of control; PCR, polymerase chain reaction; RFLP, restriction fragment length polymorphism; HRM, high-resolution melting; ARMS, amplification refractory mutation system; HWE, Hardy–Weinberg equilibrium.