|
| Genetic model | OR [95 % CI] | Z (P value) | Heterogeneity of study design | Analysis model |
| χ2 | df (P value) | I2 (%) |
|
| Mir-423 rs6505162 in total population from 12 case control studies [7, 17–27] (2,689 cases and 2,980 controls) |
| Allelic model (C-allele vs. A-allele) | 1.02 [0.81, 1.28] | 0.19 (0.85) | 73.30 | 11 (<0.001) | 85 | Random |
| Recessive model (CC vs. AC + AA) | 0.99 [0.72, 1.38] | 0.03 (0.97) | 82.60 | 11 (<0.001) | 87 | Random |
| Dominant model (AA vs. AC + CC) | 0.93 [0.72, 1.21] | 0.52 (0.60) | 21.40 | 11 (0.03) | 49 | Random |
| Homozygous model (CC vs. AA) | 1.04 [0.66, 1.65] | 0.17 (0.87) | 54.28 | 11 (<0.001) | 80 | Random |
| Heterozygous model (AC vs. AA) | 1.07 [0.90, 1.28] | 0.76 (0.45) | 11.49 | 11 (0.40) | 4 | Fixed |
|
| Mir-423 rs6505162 in Asian population from 9 case-control studies [19–27] (1,880 cases and 1,793 controls) |
| Allelic model (C-allele vs. A-allele) | 1.09 [0.82, 1.44] | 0.58 (0.56) | 47.22 | 8 (<0.001) | 83 | Random |
| Recessive model (CC vs. AC + AA) | 1.10 [0.75, 1.61] | 0.47 (0.64) | 55.74 | 8 (<0.001) | 86 | Random |
| Dominant model (AA vs. AC + CC) | 0.81 [0.63, 1.03] | 1.72 (0.09) | 11.91 | 8 (0.16) | 33 | Fixed |
| Homozygous model (CC vs. AA) | 1.20 [0.69, 2.08] | 0.64 (0.52) | 29.58 | 8(<0.001) | 73 | Random |
| Heterozygous model (AC vs. AA) | 1.20 [0.92, 1.56] | 1.35 (0.18) | 9.04 | 8(0.34) | 11 | Fixed |
|
| Mir-423 rs6505162 in Chinese population from 4 case-control studies [19–22] (1,138 cases and 1,017 controls) |
| Allelic model (C-allele vs. A-allele) | 1.12 [0.97, 1.30] | 1.50 (0.13) | 3.37 | 3 (0.34) | 11 | Fixed |
| Recessive model (CC vs. AC + AA) | 1.13 [0.95, 1.35] | 1.35 (0.18) | 4.99 | 3 (0.17) | 40 | Fixed |
| Dominant model (AA vs. AC + CC) | 0.81 [0.54, 1.22] | 1.00 (0.32) | 0.39 | 3 (0.94) | 0 | Fixed |
| Homozygous model (CC vs. AA) | 1.29 [0.85, 1.95] | 1.19 (0.24) | 0.36 | 3 (0.95) | 0 | Fixed |
| Heterozygous model (AC vs. AA) | 1.15 [0.75, 1.76] | 0.62 (0.53) | 1.10 | 3 (0.78) | 0 | Fixed |
|
| Mir-423 rs6505162 in Caucasian population from 3 case-control studies [7, 17, 18] (809 cases and 1,187 controls) |
| Allelic model (C-allele vs. A-allele) | 0.87 [0.58, 1.31] | 0.66 (0.51) | 16.19 | 2 (<0.001) | 88 | Random |
| Recessive model (CC vs. AC + AA) | 0.75 [0.38, 1.48] | 0.82 (0.41) | 17.51 | 2 (<0.001) | 89 | Random |
| Dominant model (AA vs. AC + CC) | 1.11 [0.74, 1.66] | 0.49 (0.63) | 5.80 | 2 (0.06) | 66 | Random |
| Homozygous model (CC vs. AA) | 0.75 [0.33, 1.70] | 0.70 (0.49) | 16.17 | 2 (<0.001) | 88 | Random |
| Heterozygous model (AC vs. AA) | 0.98 [0.77, 1.24] | 0.20 (0.84) | 1.25 | 2 (0.54) | 0 | Fixed |
|
| Mir-423 rs6505162 in female population from 5 case-control studies [18–21, 27] (1,356 cases and 1,155 controls) |
| Allelic model (C-allele vs. A-allele) | 1.05 [0.77, 1.42] | 0.29 (0.78) | 21.54 | 4 (<0.001) | 81 | Random |
| Recessive model (CC vs. AC + AA) | 1.06 [0.66, 1.71] | 0.24 (0.81) | 27.48 | 4 (<0.001) | 85 | Random |
| Dominant model (AA vs. AC + CC) | 1.00 [0.77, 1.30] | 0.02 (0.99) | 5.86 | 4 (0.21) | 32 | Fixed |
| Homozygous model (CC vs. AA) | 1.08 [0.52, 2.27] | 0.21 (0.83) | 21.54 | 4 (<0.001) | 81 | Random |
| Heterozygous model (AC vs. AA) | 0.95 [0.72, 1.26] | 0.34 (0.73) | 2.34 | 4 (0.67) | 0 | Fixed |
|
