Na⁺/H⁺-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer

Table 1

The transcription levels of NHE family members in between different types of CRC and colon normal tissues (ONCOMINE).

	Types of colorectal cancer versus normal	Fold change	t-test	value	Ref
NHE1	Rectal mucinous adenocarcinoma versus normal; Cecum adenocarcinoma versus normal	−2.303; −2.947	−9.275; −11.044	1.29E-9; 4.96E-14	TCGA colorectal; TCGA colorectal
	Rectal adenocarcinoma versus normal	−2.951	−15.349	9.66E-21	TCGA colorectal
	Rectosigmoid adenocarcinoma versus normal	−2.113	−11.159	3.34E-7	TCGA colorectal
	Colon adenocarcinoma versus normal	−3.158	−16.873	8.83E-18	TCGA colorectal
	Colon mucinous adenocarcinoma versus normal	−2.638	−8.124	8.44E-10	TCGA colorectal
	Rectal adenocarcinoma versus normal	−2.172	−13.622	1.98E-26	Gaedcke colorectal
	Colorectal carcinoma versus normal	−2.094	−8.314	9.40E-11	Skrzypczak colorectal
	Colorectal carcinoma versus normal	−2.099	−8.476	2.71E-9	Hong colorectal
NHE2	Rectal adenocarcinoma versus normal; Colorectal carcinoma versus normal; Colon carcinoma versus normal; Colon carcinoma epithelia versus normal; Rectosigmoid adenocarcinoma versus normal; Colon adenocarcinoma versus normal; Colorectal carcinoma versus normal	−2.492; 2.085; −4.579; −4.030; −2.399; −2.209; −6.161	−19.349; −11.349; −13.216; −5.514; −6.146; −8.368; −9.119	6.16E-40; 5.61E-15; 3.41E-9; 5.09E-5; 1.77E-5; 7.77E-6; 2.26E-11	Gaedcke colorectal; Skrzypczak colorectal; Skrzypczak colorectal 2; Skrzypczak colorectal 2; Kaiser colon; Kaiser colon; Hong colorectal
NHE3	Rectal adenoma versus normal	−3.940	−5.564	1.81E-6	Sabates-Bellver colon
	Colon adenoma versus normal	−2.763	−4.237	5.02E-5	Sabates-Bellver colon
	Rectal mucinous adenocarcinoma versus normal	−4.816	−6.531	4.37E-7	TCGA colorectal
	Rectosigmoid adenocarcinoma versus normal	−5.157	−6.477	1.69E-5	TCGA colorectal
NHE4
NHE5
NHE6
NHE7	Colon mucinous adenocarcinoma versus normal	2.169	6.000	3.79E-7	TCGA colorectal
NHE8
NHE9	Rectal adenoma versus normal	−7.304	−8.146	2.69E-7	Sabates-Bellver colon
	Colon adenoma versus normal	−2.822	−7.092	2.55E-8	Sabates-Bellver colon
	Cecum adenocarcinoma versus normal	−6.006	−12.890	6.32E-16	TCGA colorectal
	Rectal adenocarcinoma versus normal	−6.524	−17.291	2.32E-23	TCGA colorectal
	Colon mucinous adenocarcinoma versus normal	−4.656	−11.123	5.59E-14	TCGA colorectal
	Colon adenocarcinoma versus normal	−6.190	−18.898	8.28E-21	TCGA colorectal
	Rectal adenocarcinoma versus normal	−2.659	−16.026	1.27E-31	Gaedcke colorectal
NHA2	Cecum adenocarcinoma versus normal	2.392	7.819	6.42E-10	TCGA colorectal
	Colon mucinous adenocarcinoma versus normal	2.553	6.438	5.54E-8	TCGA colorectal
	Rectal adenocarcinoma versus normal	2.182	9.075	8.87E-12	TCGA colorectal
	Colon carcinoma epithelia versus normal	3.418	13.116	6.27E-6	Skrzypczak colorectal 2
	Colon carcinoma versus normal	2.544	10.192	2.34E-6	Skrzypczak colorectal 2