Na⁺/H⁺-Exchanger Family as Novel Prognostic Biomarkers in Colorectal Cancer

Table 2

GO/KEGG enrichment analysis of NHE family and its 80 interacting proteins.

Category	Term	Description	Count in gene set	value
BP	GO:0038127	ErbB signaling pathway	25	3.88E-29
BP	GO:0071900	Regulation of protein serine/threonine kinase activity	31	7.89E-24
BP	GO:0018108	Peptidyl-tyrosine phosphorylation	28	1.69E-23
BP	GO:0018212	Peptidyl-tyrosine modification	28	1.77E-23
BP	GO:0043405	Regulation of MAP kinase activity	25	1.29E-21
CC	GO:0045121	Membrane raft	13	3.30E-07
CC	GO:0098857	Membrane microdomain	13	3.30E-07
CC	GO:0005925	Focal adhesion	13	3.22E-06
CC	GO:0030055	Cell-substrate junction	13	3.22E-06
MF	GO:1990782	Protein tyrosine kinase binding	12	1.57E-12
MF	GO:0019207	Kinase regulator activity	13	1.27E-09
MF	GO:0004674	Protein serine/threonine kinase activity	13	1.82E-06
MF	GO:0046873	Metal ion transmembrane transporter activity	12	9.48E-06
KEGG	hsa04012	ErbB signaling pathway	26	5.28E-31
KEGG	hsa05205	Proteoglycans in cancer	33	1.67E-30
KEGG	hsa04010	MAPK signaling pathway	30	1.25E-21
KEGG	hsa05417	Lipid and atherosclerosis	24	6.06E-18
KEGG	hsa05163	Human cytomegalovirus infection	24	1.54E-17