TLR3 Serves as a Prognostic Biomarker and Associates with Immune Infiltration in the Renal Clear Cell Carcinoma Microenvironment

Figure 4

Cancer hallmark analysis of TLRs in KIRC. (a) Summary of genetic alterations of TLRs in KIRC (cBioportal). (b) The activation and inhibition effect of TLRs on well-known cancer-related pathways (GSCALite). The difference of pathway activity score between groups is defined by Student’s t-test. (c) Correlation heat map of TLRs in KIRC (cBioportal). This analysis was performed with Pearson’s correlation test. (d) Gene-gene interaction network of TLRs and 50 most frequently altered neighbouring genes in KIRC. This analysis was performed with Pearson’s correlation test using the TCGA KIRC data set (N = 537).

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